Zoledronic acid decreases gene expression of vascular endothelial growth factor and basic fibroblast growth factor by human epithelial cells

dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:41Z
dc.date.available2014-05-27T11:29:41Z
dc.date.created2014-05-27T11:29:41Z
dc.date.issued2013-06-17
dc.identifierBritish Journal of Oral and Maxillofacial Surgery.
dc.identifier0266-4356
dc.identifier1532-1940
dc.identifierhttp://hdl.handle.net/11449/75668
dc.identifier10.1016/j.bjoms.2013.05.010
dc.identifierWOS:000329010100059
dc.identifier2-s2.0-84878815755
dc.identifier4517484241515548
dc.description.abstractDelayed wound healing in patients taking bisphosphonates could result from decreased expression of growth factors, which are directly related to cell proliferation and migration. In this study, we evaluated the gene expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) by epithelial cells exposed to zoledronic acid 5 μmol for 48 h using real-time polymerase chain reaction. The gene expression of VEGF and bFGF by epithelial cells exposed to zoledronic acid decreased by 34% and 51%, respectively (p = 0.0001 and p = 0.0001). We conclude that zoledronic acid can decrease the expression of growth factors by epithelial cells. © 2013 The British Association of Oral and Maxillofacial Surgeons.
dc.languageeng
dc.relationBritish Journal of Oral and Maxillofacial Surgery
dc.relation1.260
dc.relation0,687
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectbFGF
dc.subjectBisphosphonates
dc.subjectEpithelial cells
dc.subjectTissue healing
dc.subjectVEGF
dc.titleZoledronic acid decreases gene expression of vascular endothelial growth factor and basic fibroblast growth factor by human epithelial cells
dc.typeArtículos de revistas


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