Anti-inflammatory and analgesic evaluation of hydroalcoholic extract and fractions from seeds of Piper cubeba L. (Piperaceae)

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorUniversity of Mississippi
dc.contributorUniversidade Federal de Ouro Preto (UFOP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:32Z
dc.date.available2014-05-27T11:29:32Z
dc.date.created2014-05-27T11:29:32Z
dc.date.issued2013-05-28
dc.identifierPharmacognosy Journal, v. 5, n. 1, p. 13-16, 2013.
dc.identifier0975-3575
dc.identifierhttp://hdl.handle.net/11449/75442
dc.identifier10.1016/j.phcgj.2012.12.001
dc.identifier2-s2.0-84878054430
dc.identifier4787521613038315
dc.identifier0000-0003-0757-7876
dc.description.abstractSome of the Piper species have been applied for the treatment of several diseases (anti-oxidant, antimicrobial, anti-inflammatory, and analgesic), considering multiple applications used in traditional medicine of different countries. About these, the present study evaluated some biological activities of Piper cubeba, as writhing test induced by acetic acid, ear edema induced by croton oil and paw edema induced by carrageenan were used by evaluated the analgesic and anti-inflammatory activities of crude hydroalcoholic extract (PCE) and its fractions of different polarities of P. cubeba L. seeds. The lethal dose (LD50) and the effective dose (ED50) were evaluated too. Both the PCE and dichloromethane fraction showed decrease values of edema and abdominal constrictions. The results obtained in this study confirm the low toxicity and analgesic and anti-inflammatory activities of PCE from P. cubeba seeds, justifying its use in folk medicine. Copyright © 2013, Phcog.Net, Published by Reed Elsevier India Pvt. Ltd. All rights reserved.
dc.languageeng
dc.relationPharmacognosy Journal
dc.relation0,176
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAnalgesic
dc.subjectAnti-inflammatory
dc.subjectPiper cubeba
dc.subjectPiperaceae
dc.subjectacetic acid
dc.subjectacetic acid ethyl ester
dc.subjectalcohol
dc.subjectanalgesic agent
dc.subjectantiinflammatory agent
dc.subjectcarrageenan
dc.subjectcroton oil
dc.subjectdexamethasone
dc.subjectdichloromethane
dc.subjecthexane
dc.subjectindometacin
dc.subjectPiper cubeba extract
dc.subjectplant extract
dc.subjectsodium chloride
dc.subjectunclassified drug
dc.subjectanalgesic activity
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantiinflammatory activity
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectear edema
dc.subjectLD 50
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpain
dc.subjectpaw edema
dc.subjectplant seed
dc.subjectrat
dc.subjectsingle drug dose
dc.subjecttoxicity testing
dc.subjectwrithing test
dc.titleAnti-inflammatory and analgesic evaluation of hydroalcoholic extract and fractions from seeds of Piper cubeba L. (Piperaceae)
dc.typeArtículos de revistas


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