Artículos de revistas
Adjunctive antimicrobial photodynamic treatment of experimentally induced periodontitis in rats with ovariectomy
Fecha
2013-04-01Registro en:
Journal of Periodontology, v. 84, n. 4, p. 556-565, 2013.
0022-3492
10.1902/jop.2012.120163
WOS:000317321100015
2-s2.0-84876124946
4068921369233125
9831236034935598
8399870097572073
8487462626931877
4408095517346846
4774447118127346
0000-0003-4859-0583
0000-0001-5650-7343
Autor
Universidade Estadual Paulista (Unesp)
Dental School of Barretos
Federal University of Alfenas
Institución
Resumen
Background: The aim of this study is to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive therapy to scaling and root planing (SRP) for the treatment of experimentally induced periodontitis in rats with ovariectomy (OVX) that are or are not treated with estrogen replacement. Methods: A total of 270 female rats were divided into three groups: 1) normal rats; 2) rats with OVX; and 3) rats with OVX with estrogen replacement. Periodontal disease was induced through the introduction of a cotton thread around the mandibular left first molar. After 7 days, the ligature was removed, and the rats were randomly divided into the following treatment groups: 1) SRP plus saline solution; 2) SRP plus low-level laser therapy (LLLT); and 3) SRP plus toluidine blue O irrigation followed by LLLT. Ten rats from each group were euthanized at days 7, 15, and 30 after dental treatment. Bone loss (BL) in the furcation region was evaluated using histometric and immunohistochemical analyses. Results: aPDT treatment resulted in reduced BL compared with SRP treatment at all time points. Additionally, rats treated with aPDT exhibited reduced numbers of tartrate-resistant acid-phosphatase-positive cells and more proliferating cell nuclear antigen-positive cells in all treatment groups regardless of estrogen status. Whereas rats treated with aPDT showed weak immunoreactivity to the receptor activator of nuclear factor-k B ligand at day 7 post-treatment, strong osteoprotegerin immunoreactivity was observed at day 15 post-treatment. Conclusion: aPDT is an effective adjunctive therapy for the treatment of periodontitis in rats with OVX that are or are not given estrogen replacement therapy.
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