Artículos de revistas
An exploratory dimensional approach to premenstrual manifestation of obsessive-compulsive disorder symptoms: A multicentre study
Journal of Psychosomatic Research, v. 74, n. 4, p. 313-319, 2013.
The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders
Federal University of Health Sciences of Porto Alegre
Universidade Estadual Paulista (UNESP)
Universidade Federal de Pernambuco (UFPE)
Universidade de São Paulo (USP)
King's College London
President Vargas Hospital for Mothers and Children
Objective: In women with obsessive-compulsive disorder (OCD), symptom severity appears to fluctuate over the course of the menstrual cycle. The objective of this paper was to compare female OCD patients with and without premenstrual worsening of obsessive-compulsive symptoms (OCS), in terms of the clinical characteristics of OCD. Methods: This was a cross-sectional study involving 455 women with OCD, of whom 226 (49.7%) had experienced premenstrual OCS worsening and 229 (50.3%) had not (PMOCS-worse and PMOCS-same groups, respectively). Data were collected with the original and dimensional versions of the Yale-Brown Obsessive-Compulsive Scale, as well as with the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Results: We found significant differences between the PMOCS-same and PMOCS-worse groups, the latter showing a higher frequency of suicidal ideation (P<.001), suicide attempts (P=.027), current use of selective serotonin reuptake inhibitors (P=.022), lifetime use of mood stabilisers (P=.015), and sexual/religious obsessions (P<.001; OR. =1.90), as well as higher scores on the BDI (P<.001) and BAI (P<.001). Conclusion: Underscoring the fact that OCD is a heterogeneous disorder, there appears to be a subgroup of female OCD patients in whom the premenstrual period is associated with a higher frequency of sexual/religious obsessions, depression, anxiety, and suicidality. This might be attributable to hormonal fluctuations. Further studies are warranted in order to investigate this hypothesis by evaluating such patients at different phases of the menstrual cycle, as well as measuring hormonal levels. © 2012 Elsevier Inc.
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Jakubovski, Ewgeni; Pittenger, Christopher; Torres, Albina Rodrigues; Fontenelle, Leonardo Franklin; do Rosario, Maria Conceicao; Ferrão, Ygor Arzeno; de Mathis, Maria Alice; Miguel, Euripedes Constantino; Bloch, Michael H.
University of Heidelberg; Yale University School of Medicine; Universidade Estadual Paulista (UNESP); Universidade Federal do Rio de Janeiro (UFRJ); Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA); Universidade de São Paulo (USP) (2011-08-15)Background: Cross-sectional studies have associated poor insight in patients with obsessive-compulsive disorder (OCD) with increased OCD symptom severity, earlier age of onset, comorbid depression, and treatment response. ...
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