Development and in vitro evaluation of coated pellets containing chitosan to potential colonic drug delivery

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorSorocaba University
dc.date.accessioned2014-05-27T11:27:33Z
dc.date.available2014-05-27T11:27:33Z
dc.date.created2014-05-27T11:27:33Z
dc.date.issued2013-01-02
dc.identifierCarbohydrate Polymers, v. 91, n. 1, p. 244-252, 2013.
dc.identifier0144-8617
dc.identifierhttp://hdl.handle.net/11449/74341
dc.identifier10.1016/j.carbpol.2012.08.044
dc.identifierWOS:000310253800032
dc.identifier2-s2.0-84865613035
dc.identifier5361569184579557
dc.description.abstractIn this work pellets containing chitosan for colonic drug delivery were developed. The influence of the polysaccharide in the pellets was evaluated by swelling, drug dissolution and intestinal permeation studies. Drug-loaded pellets containing chitosan as swellable polymer were coated with an inner layer of Kollicoat® SR 30 D and an outer layer of the enteric polymer Kollicoat® MAE 30 DP in a fluidized-bed apparatus. Metronidazole released from pellets was assessed using Bio-Dis dissolution method. Swelling, drug release and intestinal permeation were dependent on the chitosan and the coating composition. The drug release data fitted well with the Weibull equation, indicating that the drug release was controlled by diffusion, polymer relaxation and erosion occurring simultaneously. The film coating was found to be the main factor controlling the drug release and the chitosan controlling the drug intestinal permeation. Coated pellets containing chitosan show great potential as a system for drug delivery to the colon. © 2012 Elsevier Ltd.
dc.languageeng
dc.relationCarbohydrate Polymers
dc.relation5.158
dc.relation1,428
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectChitosan
dc.subjectColonic drug delivery
dc.subjectEnteric coating
dc.subjectIntestinal permeation
dc.subjectMetronidazole
dc.subjectPellets
dc.subjectCoating compositions
dc.subjectDissolution methods
dc.subjectDrug dissolution
dc.subjectDrug release
dc.subjectEnteric polymer
dc.subjectEnteric-coating
dc.subjectFilm coatings
dc.subjectIn-vitro evaluation
dc.subjectInner layer
dc.subjectKollicoat
dc.subjectOuter layer
dc.subjectPolymer relaxations
dc.subjectSwellable polymers
dc.subjectWeibull
dc.subjectDrug delivery
dc.subjectDrug products
dc.subjectFluidized beds
dc.subjectOre pellets
dc.subjectPelletizing
dc.subjectPlastic coatings
dc.subjectPolymers
dc.subjectProtective coatings
dc.subjectchitosan
dc.subjectdrug carrier
dc.subjectmetronidazole
dc.subjectpolyvinyl acetate
dc.subjectpolyvinyl derivative
dc.subjectanimal
dc.subjectchemistry
dc.subjectcolon
dc.subjectintestine absorption
dc.subjectkinetics
dc.subjectmale
dc.subjectmetabolism
dc.subjectpermeability
dc.subjectrat
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectColon
dc.subjectDrug Carriers
dc.subjectIntestinal Absorption
dc.subjectKinetics
dc.subjectMale
dc.subjectPermeability
dc.subjectPolyvinyls
dc.subjectRats
dc.subjectRats, Wistar
dc.titleDevelopment and in vitro evaluation of coated pellets containing chitosan to potential colonic drug delivery
dc.typeArtículos de revistas


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