Artículos de revistas
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues
Fecha
2012-12-01Registro en:
Surgical and Cosmetic Dermatology, v. 4, n. 3, p. 229-236, 2012.
1984-5510
1984-8773
2-s2.0-84872871156
2-s2.0-84872871156.pdf
Autor
Chemyunion Química Ltda.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
Specialization in Cosmetics Safety Evaluation from the Vrije Universiteit
Mantecorp Indústria Química e Farmacêutica Ltda.
Universidade Estadual Paulista (Unesp)
KOLderma Instituto de Pesquisa Clínica Ltda
Institución
Resumen
Introduction: Aging skin is a condition that affects (or will affect) all people, and its treatment is considered a clinical challenge. Growth factors and their analogues are emerging as a promising therapeutic option. Objectives: To evaluate the safety profile of some dermocosmetic products with formulations based on growth factors - or their analogs intended for that purpose - using in vitro human skin cell culture models. Methods: Two types of cell cultures were studied, and the effects of the study products on the proliferation of melanoma cells and normal human fibroblasts were evaluated. Results: No significant morphological alterations were found in the cultured human melanoma, and no significant decrease in the number of healthy cells was verified in the normal fibroblasts culture. In some cases there was even a proliferation of those cells. Conclusions: These preliminary data demonstrate that cosmeceutical products containing growth factors as an active principle can be considered safe for topical application.