dc.contributorFaculdade de Medicina do ABC (FMABC)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal do Acre (UFAC)
dc.date.accessioned2014-05-27T11:26:23Z
dc.date.available2014-05-27T11:26:23Z
dc.date.created2014-05-27T11:26:23Z
dc.date.issued2012-02-08
dc.identifierInternational Archives of Medicine, v. 5, n. 1, 2012.
dc.identifier1755-7682
dc.identifierhttp://hdl.handle.net/11449/73185
dc.identifier10.1186/1755-7682-5-4
dc.identifier2-s2.0-84856563119
dc.identifier2-s2.0-84856563119.pdf
dc.description.abstractIn this minireview we describe the involvement of the atrial natriuretic peptide (ANP) in cardiovascular pathophysiology and exercise. The ANP has a broad homeostatic role and exerts complex effects on the cardio-circulatory hemodynamics, it is produced by the left atrium and has a key role in regulating sodium and water balance in mammals and humans. The dominant stimulus for its release is atrial wall tension, commonly caused by exercise. The ANP is involved in the process of lipolysis through a cGMP signaling pathway and, as a consequence, reducing blood pressure by decreasing the sensitivity of vascular smooth muscle to the action of vasoconstrictors and regulate fluid balance. The increase of this hormone is associated with better survival in patients with chronic heart failure (CHF). This minireview provides new evidence based on recent studies related to the beneficial effects of exercise in patients with cardiovascular disease, focusing on the ANP. © 2012 de Almeida et al; licensee BioMed Central Ltd.
dc.languageeng
dc.relationInternational Archives of Medicine
dc.relation0,237
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectadenylate cyclase
dc.subjectaldosterone
dc.subjectangiotensin II
dc.subjectatrial natriuretic factor
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectcatecholamine
dc.subjectcyclic GMP
dc.subjectendothelin
dc.subjectinsulin
dc.subjectperilipin
dc.subjectrenin
dc.subjectvasopressin
dc.subjectblood pressure
dc.subjectblood vessel tone
dc.subjectcardiovascular system
dc.subjectcoronary artery disease
dc.subjectdehydration
dc.subjectdisease course
dc.subjectenzyme activity
dc.subjectexercise
dc.subjectfluid balance
dc.subjectglomerulus filtration
dc.subjectheart failure
dc.subjectheart function
dc.subjectheart hemodynamics
dc.subjectheart left atrium
dc.subjecthormone determination
dc.subjecthuman
dc.subjectkidney function
dc.subjectkidney tubule absorption
dc.subjectlipolysis
dc.subjectnitrogen balance
dc.subjectpathophysiology
dc.subjectphosphorylation
dc.subjectprognosis
dc.subjectreview
dc.subjectsignal transduction
dc.subjectsurvival
dc.subjecturinary excretion
dc.subjectvascular resistance
dc.subjectvascular smooth muscle
dc.subjectvasoconstriction
dc.subjectvenous oxygen tension
dc.titleInvolvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise
dc.typeOtros


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