Effect of exercise training on the cardiovascular and biochemical parameters in women with eNOS gene polymorphism

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:26:15Z
dc.date.available2014-05-27T11:26:15Z
dc.date.created2014-05-27T11:26:15Z
dc.date.issued2011-12-01
dc.identifierArchives of Physiology and Biochemistry, v. 117, n. 5, p. 265-269, 2011.
dc.identifier1381-3455
dc.identifier1744-4160
dc.identifierhttp://hdl.handle.net/11449/72899
dc.identifier10.3109/13813455.2011.596548
dc.identifier2-s2.0-82455171766
dc.identifier4472007237545596
dc.description.abstractContext: Presence of endothelial nitric oxide synthase (eNOS) gene polymorphism has been associated with cardiovascular disease (CVD) whereas exercise training (EX) promotes beneficial effects on CVD which is related to increased nitric oxide levels (NO). Objective: To evaluate if women with eNOS gene polymorphism at position-G894T would be less responsive to EX than those who did not carry T allele. Methods: Women were trained 3 days/week, 40 minutes session during 6 months. Cardio-biochemical parameters and genetic analysis were performed in a double-blind fashion. Results: Plasma NOx - levels were similar in both groups at baseline (GG genotype: 18.44±3.28 μM) and (GT + TT genotype: 17.19±2.43 μM) and after EX (GG: 29.20±4.33 and GT+TT: 27.38±3.12 μM). A decrease in blood pressure was also observed in both groups. Discussion and conclusion: The presence of eNOS polymorphism does not affect the beneficial effects of EX in women. © 2011 Informa UK, Ltd.
dc.languageeng
dc.relationArchives of Physiology and Biochemistry
dc.relation1.806
dc.relation0,626
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectBlood pressure
dc.subjectNitric oxide
dc.subjectPhysical training
dc.subjectWomen
dc.subjectendothelial nitric oxide synthase
dc.subjectnitric oxide
dc.subjectNOS3 protein, human
dc.subjectallele
dc.subjectbiosynthesis
dc.subjectblood
dc.subjectblood pressure
dc.subjectBrazil
dc.subjectcardiovascular disease
dc.subjectcase control study
dc.subjectdouble blind procedure
dc.subjectenzymology
dc.subjectexercise
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetics
dc.subjectgenotype
dc.subjecthuman
dc.subjectmiddle aged
dc.subjectsingle nucleotide polymorphism
dc.subjectAlleles
dc.subjectBlood Pressure
dc.subjectCardiovascular Diseases
dc.subjectCase-Control Studies
dc.subjectDouble-Blind Method
dc.subjectExercise
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectNitric Oxide
dc.subjectNitric Oxide Synthase Type III
dc.subjectPolymorphism, Single Nucleotide
dc.titleEffect of exercise training on the cardiovascular and biochemical parameters in women with eNOS gene polymorphism
dc.typeArtículos de revistas


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