Artículos de revistas
Dermatoses bolhosas auto-imunes
Fecha
2009-03-01Registro en:
Anais Brasileiros de Dermatologia, v. 84, n. 2, p. 111-122, 2009.
0365-0596
1806-4841
10.1590/S0365-05962009000200003
S0365-05962009000200003
2-s2.0-67449127608
2-s2.0-67449127608.pdf
Autor
Faculdade de Medicina de Jundiaí (FMJ)
Universidade de São Paulo (USP)
New York University
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Autoimmune bullous dermatoses are diseases in which blisters and vesicles are the primary and fundamental types of skin lesion. Their classification is based on the location of the blister: intraepidermal and subepidermal. Patients produce autoantibodies against self-specific structures of the skin detectable by immunofluorescence techniques, immunoblotting and ELISA. Recent advances in molecular and cellular biology have brought to knowledge these self-antigens, against which patients are sensitized, and which are found in epidermis or in the dermo-epidermal junction. These are low incidence, but high morbidity diseases that may be fatal. The aim of this article is to review and describe the progress of four autoimmune vesiculobullous disorders: endemic pemphigus foliaceous (wild fire), pemphigus vulgaris, bullous pemphigoid and dermatitis herpetiformis. ©2009 by Anais Brasileiros de Dermatologia.