Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays

dc.contributorUniversidade de Franca (UNIFRAN)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorCentro Universitário Moura Lacerda
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:37Z
dc.date.available2014-05-27T11:23:37Z
dc.date.created2014-05-27T11:23:37Z
dc.date.issued2008-07-30
dc.identifierGenetics and Molecular Research, v. 7, n. 2, p. 467-475, 2008.
dc.identifier1676-5680
dc.identifierhttp://hdl.handle.net/11449/70498
dc.identifier10.4238/vol7-2gmr414
dc.identifier2-s2.0-47949095090
dc.identifier2-s2.0-47949095090.pdf
dc.description.abstractAs a contribution towards detecting the genetic effects of low doses of genotoxic physical agents, this paper deals with the consequences of low-dose X-rays in the Aspergillus nidulans genome. The irradiation doses studied were those commonly used in dental clinics (1-5 cGy). Even very low doses promoted increased mitotic crossing-over frequencies in diploid strains heterozygous for several genetic markers including the ones involved in DNA repair and recombination mechanisms. Genetic markers of several heterozygous strains were individually analyzed disclosing that some markers were especially sensitive to the treatments. These markers should be chosen as bio-indicators in the homozygotization index assay to better detect the recombinogenic/ carcinogenic genomic effects of low-dose X-rays. ©FUNPEC-RP.
dc.languageeng
dc.relationGenetics and Molecular Research
dc.relation0,439
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAspergillus nidulans
dc.subjectDNA damage
dc.subjectGenotoxicity tests
dc.subjectHomozygotization index assay
dc.subjectLow-dose X-rays
dc.subjectMitotic crossing-over
dc.subjectcontrolled study
dc.subjectcrossing over
dc.subjectdiploidy
dc.subjectDNA recombination
dc.subjectDNA repair
dc.subjectfungal gene
dc.subjectfungal strain
dc.subjectgenotoxicity
dc.subjectlow energy radiation
dc.subjectmitosis
dc.subjectnonhuman
dc.subjectradiation mutagenesis
dc.subjectX irradiation
dc.subjectCrossing Over, Genetic
dc.subjectDiploidy
dc.subjectDNA Damage
dc.subjectDose-Response Relationship, Radiation
dc.subjectHomozygote
dc.subjectMitosis
dc.subjectMutagenicity Tests
dc.subjectX-Rays
dc.subjectEmericella nidulans
dc.titleInduction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays
dc.typeArtículos de revistas


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