Vernonia polyanthes as a new source of antiulcer drugs

dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:39Z
dc.date.available2014-05-27T11:22:39Z
dc.date.created2014-05-27T11:22:39Z
dc.date.issued2007-12-01
dc.identifierFitoterapia, v. 78, n. 7-8, p. 545-551, 2007.
dc.identifier0367-326X
dc.identifierhttp://hdl.handle.net/11449/70008
dc.identifier10.1016/j.fitote.2007.07.003
dc.identifier2-s2.0-35448985425
dc.identifier3814504901386844
dc.identifier0000-0002-8645-3777
dc.identifier0000-0003-3032-2556
dc.description.abstractMethanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.
dc.languageeng
dc.relationFitoterapia
dc.relation2.642
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAction mechanisms
dc.subjectAntiulcerogenic activity
dc.subjectVernonia polyanthes
dc.subjectalcohol
dc.subjectantiulcer agent
dc.subjectcarbenoxolone
dc.subjectcimetidine
dc.subjectlansoprazole
dc.subjectn ethylmaleimide
dc.subjectn(g) nitroarginine methyl ester
dc.subjectnonsteroid antiinflammatory agent
dc.subjectpiroxicam
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectvernonia polyanthes chloroformic extract
dc.subjectVernonia polyanthes extract
dc.subjectvernonia polyanthes methanolic extract
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectdrug inhibition
dc.subjectdrug mechanism
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectstomach mucosa lesion
dc.subjectvernonia polyanthes
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectAnti-Ulcer Agents
dc.subjectDose-Response Relationship, Drug
dc.subjectEthanol
dc.subjectMale
dc.subjectPhytotherapy
dc.subjectPlant Components, Aerial
dc.subjectPlant Extracts
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStomach Ulcer
dc.subjectVernonia
dc.titleVernonia polyanthes as a new source of antiulcer drugs
dc.typeArtículos de revistas


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