Artículos de revistas
Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs
Fecha
2007-03-01Registro en:
American Journal of Veterinary Research, v. 68, n. 3, p. 258-264, 2007.
0002-9645
10.2460/ajvr.68.3.258
2-s2.0-33947662010
4473260410099623
3517825410178813
1087615389013655
0000-0003-3323-4199
0000-0001-5312-9076
0000-0002-2011-5214
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Objective - To evaluate adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. Animals - 36 adult dogs. Procedures - Values for CBC, urinalysis, serum biochemical urinalyses, and occult blood in feces were investigated before and 7, 30, 60, and 90 days after daily oral administration (n = 6 dogs/group) of lactose (1 mg/kg, control treatment), etodolac (15 mg/kg), meloxicam (0.1 mg/kg), carprofen (4 mg/kg), and ketoprofen (2 mg/kg for 4 days, followed by 1 mg/kg daily thereafter) or flunixin (1 mg/kg for 3 days, with 4-day intervals). Gastroscopy was performed before and after the end of treatment. Results - For serum γ-glutamyltransferase activity, values were significantly increased at day 30 in dogs treated with lactose, etodolac, and meloxicam within groups. Bleeding time was significantly increased in dogs treated with carprofen at 30 and 90 days, compared with baseline. At 7 days, bleeding time was significantly longer in dogs treated with meloxicam, ketoprofen, and flunixin, compared with control dogs. Clotting time increased significantly in all groups except those treated with etodolac. At day 90, clotting time was significantly shorter in flunixin-treated dogs, compared with lactose-treated dogs. Gastric lesions were detected in all dogs treated with etodolac, ketoprofen, and flunixin, and 1 of 6 treated with carprofen. Conclusions and Clinical Relevance - Carprofen induced the lowest frequency of gastrointestinal adverse effects, followed by meloxicam. Monitoring for adverse effects should be considered when nonsteroidal anti-inflammatory drugs are used to treat dogs with chronic pain.
Materias
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Relationship between irisin concentration and serum cytokines in mother and newborn
Estibalitz Laresgoiti Servitje; Gerardo de Jesús García Rivas -
Dietary, anthropometric, and biochemical determinants of uric acid in free-living adults
De Oliveira, Erick Prado; Moreto, Fernando; Silveira, Liciana Vaz de Arruda; Burini, Roberto Carlos -
Dietary, anthropometric, and biochemical determinants of uric acid in free-living adults
Universidade Estadual Paulista (Unesp) (2013-01-16)Background: High plasma uric acid (UA) is a prerequisite for gout and is also associated with the metabolic syndrome and its components and consequently risk factors for cardiovascular diseases. Hence, the management of ...