dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUNIP - Araçatuba
dc.contributorFaculdades Católicas Salesianas
dc.contributorSchool of Medicine
dc.date.accessioned2014-05-27T11:21:48Z
dc.date.available2014-05-27T11:21:48Z
dc.date.created2014-05-27T11:21:48Z
dc.date.issued2006-01-28
dc.identifierWorld Journal of Gastroenterology, v. 12, n. 4, p. 625-629, 2006.
dc.identifier1007-9327
dc.identifierhttp://hdl.handle.net/11449/68765
dc.identifierWOS:000239947400020
dc.identifier2-s2.0-33644907463
dc.identifier2-s2.0-33644907463.pdf
dc.description.abstractAim: To investigate the occurrence of chromosome 3, 7, 8, 9, and 17 aneuploidies, TP53 gene deletion and p53 protein expression in chronic gastritis, atrophic gastritis and gastric ulcer, and their association with H pylori infection. Methods: Gastric biopsies from normal mucosa (NM, n = 10), chronic gastritis (CG, n = 38), atrophic gastritis (CAG, n = 13) and gastric ulcer (GU, n = 21) were studied using fluorescence in situ hybridization (FISH) and immunohistochemical assay. A modified Giemsa staining technique and PCR were used to detect H pylori. An association of the gastric pathologies and aneuploidies with H pylori infection was assessed. Results: Aneuploidies were increasingly found from CG (21%) to CAG (31%) and to GU (62%), involving mainly monosomy and trisomy 7, trisomies 7 and 8, and trisomies 7, 8 and 17, respectively. A significant association was found between H pylori infection and aneuploidies in CAG (P = 0.0143) and GU (P = 0.0498). No TP53 deletion was found in these gastric lesions, but p53-positive immunoreactivity was detected in 45% (5/11) and 12% (2/17) of CG and GU cases, respectively. However, there was no significant association between p53 expression and H pylori infection. Conclusion: The occurrence of aneuploidies in benign lesions evidences chromosomal instability in early stages of gastric carcinogenesis associated with H pylori infection, which may confer proliferative advantage. The increase of p53 protein expression in CG and GU may be due to overproduction of the wild-type protein related to an inflammatory response in mucosa. © 2006 The WJG Press. All rights reserved.
dc.languageeng
dc.relationWorld Journal of Gastroenterology
dc.relation3.300
dc.relation1,409
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAneuploidies
dc.subjectGastric ulcer
dc.subjectGastritis
dc.subjectp53 protein
dc.subjectTP53 gene
dc.subjectprotein p53
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectaneuploidy
dc.subjectatrophic gastritis
dc.subjectbacterium detection
dc.subjectcell proliferation
dc.subjectchild
dc.subjectchromosomal instability
dc.subjectchromosome 17
dc.subjectchromosome 3
dc.subjectchromosome 7
dc.subjectchromosome 8
dc.subjectchromosome 9
dc.subjectchronic gastritis
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdisease association
dc.subjectfemale
dc.subjectfluorescence in situ hybridization
dc.subjectgene deletion
dc.subjectGiemsa stain
dc.subjectHelicobacter infection
dc.subjectHelicobacter pylori
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectinflammation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmonosomy 7
dc.subjectnonhuman
dc.subjectpolymerase chain reaction
dc.subjectprotein expression
dc.subjectprotein synthesis
dc.subjectstomach biopsy
dc.subjectstomach carcinogenesis
dc.subjectstomach mucosa
dc.subjectstomach ulcer
dc.subjecttrisomy
dc.subjecttrisomy 17
dc.subjecttrisomy 7
dc.subjecttrisomy 8
dc.subjectwild type
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAneuploidy
dc.subjectChild, Preschool
dc.subjectChronic Disease
dc.subjectFemale
dc.subjectGene Deletion
dc.subjectGenes, p53
dc.subjectHelicobacter Infections
dc.subjectHumans
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectStomach Ulcer
dc.subjectTumor Suppressor Protein p53
dc.titleGenetic alterations in benign lesions: Chronic gastritis and gastric ulcer
dc.typeArtículos de revistas


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