dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:37Z
dc.date.available2014-05-27T11:21:37Z
dc.date.created2014-05-27T11:21:37Z
dc.date.issued2005-09-01
dc.identifierJournal of Nutrition, v. 135, n. 9, p. 2109-2113, 2005.
dc.identifier0022-3166
dc.identifierhttp://hdl.handle.net/11449/68403
dc.identifier2-s2.0-24744463574
dc.identifier6990977122340795
dc.identifier6309835137998766
dc.identifier5016839015394547
dc.identifier1213140801402647
dc.identifier7438704034471673
dc.identifier0000-0002-5843-6232
dc.description.abstractThe objective of this study was to investigate the effects of exposure to tobacco smoke (ETS) in rats that were or were not supplemented with dietary β-carotene (BC), on ventricular remodeling and survival after myocardial infarction (Ml). Rats (n = 189) were allocated to 4 groups: the control group, n = 45; group BC administered 500 mg/kg diet, n = 49, BC supplemented rats; group ETS, n - 55, rats exposed to tobacco smoke; and group BC+ETS, n = 40. Wistar rats weighing 10O g were administered one of the treatments until they weighed 200 to 250 g (∼5 wk). The ETS rats were exposed to cigarette smoke for 30 min 4 times/d, in a chamber connected to a smoking device. After reaching a weight of 200-250 g, rats were subjected to experimental MI (coronary artery occlusion) and mortality rates were determined over the next 105 d. In addition, echocardiographic, isolated heart, morphometrical, and biochemical studies were performed. Mortality data were tested using Kaplan-Meyer curves and other data by 2-way ANOVA. Survival rates were greater in the ETS group (58.2%) than in the control (33.3%) (P = 0.001) and BC+ETS rats (30.0%) (P = 0.007). The groups did not differ in the other comparisons. Left ventricular end-diastolic diameter normalized to body weight was greater and maximal systolic pressures were lower in the ETS groups than in non-ETS groups. Previous exposure to tobacco smoke induced a process of cardiac remodeling after MI. There is a paradoxical protector effect with tobacco smoke exposure, characterized by lower mortality, which is offset by BC supplementation. © 2005 American Society for Nutritional Sciences.
dc.languageeng
dc.relationJournal of Nutrition
dc.relation4.398
dc.relation2,191
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectβ-carotene
dc.subjectMyocardial infarction
dc.subjectParadoxical effect
dc.subjectSmoking
dc.subjectVentricular remodeling
dc.subjectbeta carotene
dc.subjectcigarette smoke
dc.subjecttobacco smoke
dc.subjectanalysis of variance
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectdisease model
dc.subjectechocardiography
dc.subjectheart infarction
dc.subjectheart left ventricle enddiastolic volume
dc.subjectheart protection
dc.subjectimage analysis
dc.subjectisolated heart
dc.subjectKaplan Meier method
dc.subjectmale
dc.subjectmorphometrics
dc.subjectmortality
dc.subjectnonhuman
dc.subjectrat
dc.subjectrat strain
dc.subjectsmoking
dc.subjectsurvival rate
dc.subjectsystolic blood pressure
dc.subjectAnimals
dc.subjectbeta Carotene
dc.subjectDiet
dc.subjectEchocardiography
dc.subjectHeart
dc.subjectMale
dc.subjectMyocardial Infarction
dc.subjectMyocardium
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSmoke
dc.subjectSurvival Analysis
dc.subjectTobacco
dc.subjectVentricular Remodeling
dc.subjectNicotiana tabacum
dc.subjectRattus norvegicus
dc.titleβ-carotene attenuates the paradoxical effect of tobacco smoke on the mortality of rats after experimental myocardial infarction
dc.typeArtículos de revistas


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