Sensitivity of AMPA receptor channel to calcium oscillations: A computational study

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:20:39Z
dc.date.available2014-05-27T11:20:39Z
dc.date.created2014-05-27T11:20:39Z
dc.date.issued2003-06-01
dc.identifierNeurocomputing, v. 52-54, p. 341-346.
dc.identifier0925-2312
dc.identifierhttp://hdl.handle.net/11449/67296
dc.identifier10.1016/S0925-2312(02)00828-7
dc.identifierWOS:000183514300051
dc.identifier2-s2.0-0038721242
dc.description.abstractWe used a computational model of biochemical pathways that are involved in the phosphorylation/dephosphorylation of AMPA receptor to study the receptor responses to calcium oscillations. In the model, the biochemical pathways are assumed to be located immediately under the postsynaptic membrane and we included three states of AMPA receptor: dephosphorylated, and phosphorylated in one or in two sites. To characterize the effects of calcium oscillations on the AMPA receptor, we exposed the model to stimuli with three varying parameters, namely frequency, number of pulses and calcium spike duration. Our model showed sensitivity to all of these three parameters. © 2002 Elsevier Science B.V. All rights reserved.
dc.languageeng
dc.relationNeurocomputing
dc.relation3.241
dc.relation1,073
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAMPA receptor
dc.subjectBiochemical networks
dc.subjectCalcium oscillations
dc.subjectPlasticity
dc.subjectCalcium
dc.subjectCell membranes
dc.subjectSensitivity analysis
dc.subjectPhosphorylation
dc.subjectBiochemistry
dc.subjectcalcium
dc.subjectbiochemistry
dc.subjectcalcium signaling
dc.subjectchemical parameters
dc.subjectcomputer program
dc.subjectcomputer simulation
dc.subjectcontrolled study
dc.subjectdephosphorylation
dc.subjectfrequency modulation
dc.subjectmathematical model
dc.subjectpostsynaptic membrane
dc.subjectpriority journal
dc.subjectprotein phosphorylation
dc.subjectsensitivity analysis
dc.subjectspike wave
dc.titleSensitivity of AMPA receptor channel to calcium oscillations: A computational study
dc.typeArtículos de revistas


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