dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-27T11:20:30Z | |
dc.date.available | 2014-05-27T11:20:30Z | |
dc.date.created | 2014-05-27T11:20:30Z | |
dc.date.issued | 2002-10-01 | |
dc.identifier | Pesquisa odontológica brasileira = Brazilian oral research, v. 16, n. 4, p. 361-365, 2002. | |
dc.identifier | 1806-8324 | |
dc.identifier | http://hdl.handle.net/11449/66990 | |
dc.identifier | 10.1590/S1517-74912002000400014 | |
dc.identifier | S1517-74912002000400014 | |
dc.identifier | 2-s2.0-0037518290 | |
dc.identifier | 2-s2.0-0037518290.pdf | |
dc.description.abstract | The utilization of dentifrices with low fluorine concentration, for children under 6 years of age, has been suggested to reduce the risks of dental fluorosis. However, in order to have anticariogenic potential, the dentifrice should form loosely-bound fluorine (CaF2) on dental enamel. Considering that the formation of CaF2 is a function inversely related to pH, dentifrices with pH 5.5, with 275, 550 and 1,100 ppm F (NaF/silica) were developed in order to assess dose-response effects. A comparison between those dentifrices, a placebo product and the Crest toothpaste (positive control - standard) was carried out. Furthermore, the bioavailability of dentifrices, in terms of formation of total fluorine (TF), CaF2, and fluorapatite (FA) on human dental enamel, was evaluated. An ion-specific electrode was utilized for the determination of the dosage of fluorine. The results revealed that the dentifrice with 550 ppm F was more effective than both the placebo and the dentifrice with 275 ppm, presenting no difference in relation to the positive control (p > 0.05). A dose-effect correlation was observed as to the CaF2 formed. In conclusion, the modified formulation with 550 ppm F can be considered as effective as the standard dentifrice with 1,100 ppm, and its utilization would be safer with regard to dental fluorosis. | |
dc.language | por | |
dc.relation | Pesquisa Odontológica Brasileira = Brazilian Oral Research | |
dc.rights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | apatite | |
dc.subject | fluorapatite | |
dc.subject | fluoride | |
dc.subject | fluorine | |
dc.subject | toothpaste | |
dc.subject | bone prosthesis | |
dc.subject | chemistry | |
dc.subject | clinical trial | |
dc.subject | controlled clinical trial | |
dc.subject | controlled study | |
dc.subject | dental caries | |
dc.subject | dose response | |
dc.subject | drug effect | |
dc.subject | enamel | |
dc.subject | human | |
dc.subject | molar tooth | |
dc.subject | preschool child | |
dc.subject | tooth crown | |
dc.subject | tooth disease | |
dc.subject | Apatites | |
dc.subject | Bone Substitutes | |
dc.subject | Child, Preschool | |
dc.subject | Dental Caries | |
dc.subject | Dental Enamel | |
dc.subject | Dose-Response Relationship, Drug | |
dc.subject | Fluorides | |
dc.subject | Fluorine | |
dc.subject | Fluorosis, Dental | |
dc.subject | Humans | |
dc.subject | Molar, Third | |
dc.subject | Tooth Crown | |
dc.subject | Toothpaste | |
dc.title | Efeito dose-resposta de uma formulação de dentifrício com concentração reduzida de fluoreto - estudo in vitro. | |
dc.type | Artículos de revistas | |