Artículos de revistas
Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves
Fecha
1998-06-10Registro en:
Clinical and Diagnostic Laboratory Immunology, v. 5, n. 3, p. 294-298, 1998.
1071-412X
WOS:000073471300005
2-s2.0-0031804082
Autor
Compton Laboratory
Universidade Estadual Paulista (Unesp)
Institución
Resumen
A lytic bacteriophage, which was previously isolated from sewage and which attaches to the K1 capsular antigen, has been used to prevent septicemia and a meningitis-like infection in chickens caused by a K1+ bacteremic strain of Escherichia coli. Protection was obtained even when administration of the phage was delayed until signs of disease appeared. The phage was able to multiply in the blood. In newly borne colostrum-deprived calves given the E. coli orally, intramuscular inoculation of phage delayed appearance of the bacterium in the blood and lengthened life span. With some provisos there is considerable potential for this approach to bacterial-disease therapy.