On a dual role for clonidine stimulation of the ventromedial nucleus of the hypothalamus in sodium and potassium renal excretions of rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:07Z
dc.date.available2014-05-27T11:18:07Z
dc.date.created2014-05-27T11:18:07Z
dc.date.issued1996-11-01
dc.identifierPharmacology. Basel: Karger, v. 53, n. 5, p. 281-288, 1996.
dc.identifier0031-7012
dc.identifierhttp://hdl.handle.net/11449/64872
dc.identifier10.1159/000139440
dc.identifierWOS:A1996VY81500002
dc.identifier2-s2.0-10544222836
dc.description.abstractThe effects of clonidine on sodium and potassium excretions were examined after previous administration of prazosin (an α 1-adrenergic receptor antagonist) and yohimbine (an α 2-adrenergic receptor antagonist) into the ventromedial nucleus of the hypothalamus of conscious rats. Clonidine injected into the ventromedial nucleus of the hypothalamus induced inhibitory and facilitatory effects on the urinary sodium and potassium excretions. The results suggest that facilitatory effects of clonidine on natriuresis and kaliuresis are mediated through activation of α 1-adrenoceptors and that inhibitory effects require α(2A)-adrenoceptors.
dc.languageeng
dc.relationPharmacology
dc.relation1.538
dc.relation0,502
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectClonidine
dc.subjectPotassium excretion
dc.subjectPrazosin
dc.subjectSodium excretion
dc.subjectVentromedical nucleus, hypothalamus
dc.subjectYohimbine
dc.subjectalpha 1 adrenergic receptor
dc.subjectalpha 2A adrenergic receptor
dc.subjectalpha adrenergic receptor stimulating agent
dc.subjectclonidine
dc.subjectpotassium ion
dc.subjectprazosin
dc.subjectsodium ion
dc.subjectyohimbine
dc.subjectanimal experiment
dc.subjectcontrolled study
dc.subjectintracerebral drug administration
dc.subjectkaliuresis
dc.subjectmale
dc.subjectnatriuresis
dc.subjectnonhuman
dc.subjectpotassium urine level
dc.subjectpriority journal
dc.subjectrat
dc.subjectsodium urine level
dc.subjectstimulation
dc.subjectthalamus ventral nucleus
dc.subjectAdrenergic alpha-Antagonists
dc.subjectAnimals
dc.subjectDose-Response Relationship, Drug
dc.subjectHypothalamus
dc.subjectKidney
dc.subjectMale
dc.subjectPotassium
dc.subjectRats
dc.subjectSodium
dc.titleOn a dual role for clonidine stimulation of the ventromedial nucleus of the hypothalamus in sodium and potassium renal excretions of rats
dc.typeArtículos de revistas


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