Genetic susceptibility to bleomycin: A twin study

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:59Z
dc.date.available2014-05-27T11:17:59Z
dc.date.created2014-05-27T11:17:59Z
dc.date.issued1995-01-01
dc.identifierRevista de Ciencias Biomedicas, v. 16, p. 47-53.
dc.identifier0101-322X
dc.identifierhttp://hdl.handle.net/11449/64586
dc.identifier2-s2.0-0028871898
dc.description.abstractThe frequency of chromatid breaks was analysed in peripheral lymphocytes obtained from sixteen healthy monozygotic (MZ) and sixteen healthy dizygotic (DZ) pairs of twins. In addition, increases in the frequency of chromatid breaks, following in vitro treatment of whole blood with 0.03 unit/ml bleomycin (BLM), were analysed in the same twins. There was a highly significant intrapair difference in the variance of the frequency of chromatid breaks among MZ and DZ twins, before and after BLM treatment. The coefficient of heritability was 85,5% and it was concluded that genetic factors contributed significantly to the individual variation observed in BLM induced chromatid break rates.
dc.languageeng
dc.relationRevista de Ciencias Biomedicas
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectbleomycin
dc.subjecttwins
dc.subjectvariation (genetics)
dc.subjectadolescent
dc.subjectadult
dc.subjectchild
dc.subjectchromatid
dc.subjectchromosome breakage
dc.subjectdizygotic twins
dc.subjectfemale
dc.subjectgenetic susceptibility
dc.subjectheredity
dc.subjecthuman
dc.subjecthuman experiment
dc.subjectin vitro study
dc.subjectmale
dc.subjectmonozygotic twins
dc.subjectnormal human
dc.titleGenetic susceptibility to bleomycin: A twin study
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución