dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Univ Vet Med Hannover | |
dc.contributor | Univ Utrecht | |
dc.date.accessioned | 2014-05-20T15:30:20Z | |
dc.date.available | 2014-05-20T15:30:20Z | |
dc.date.created | 2014-05-20T15:30:20Z | |
dc.date.issued | 2009-07-01 | |
dc.identifier | Reproduction In Domestic Animals. Malden: Wiley-blackwell Publishing, Inc, v. 44, p. 320-325, 2009. | |
dc.identifier | 0936-6768 | |
dc.identifier | http://hdl.handle.net/11449/39744 | |
dc.identifier | 10.1111/j.1439-0531.2009.01425.x | |
dc.identifier | WOS:000267756400068 | |
dc.identifier | 3725971100777730 | |
dc.description.abstract | Effects of a short-term hyper- and hypoprolactinaemia on serum concentrations of LH, testosterone and semen quality in six male Beagles were investigated. Blood samples were collected at 3-day intervals for 12 weeks. The time span was divided into five 3-week periods: pre-treatment, metoclopramide (MCP) treatment (0.2 mg/kg orally three times daily), cabergoline (CAB) treatment (5 mu g/kg orally once daily), post-treatment 1 and post-treatment 2. In the latter, only semen characteristics were evaluated. Semen parameters were analyzed once per week during the whole 15-week investigation time. At the end of each period, the effects of a single intravenous injection of thyrotropin-releasing hormone (TRH; 10 mu g/kg) on the secretion of prolactin (PRL), LH, testosterone, thyroid-stimulating hormone and thyroxine (T4) were investigated. Pre-treatment serum PRL concentration increased under MCP (p < 0.05), followed by a decrease under CAB administration (p < 0.05). Luteinizing hormone and testosterone concentrations were not affected. Except for straight-line sperm velocity, semen quality did not differ between collection periods. A single iv TRH injection induced a significant PRL increase at 20 min in all experimental periods except during CAB treatment. Luteinizing hormone and testosterone did not show clear TRH-related changes. Basic T4 levels were significantly reduced after CAB treatment ( p < 0.05). The results of the present study demonstrate that MCP-induced short-term hyperprolactinaemia in male beagles does not seriously affect the hypothalamo-pituitary axis and semen quality. | |
dc.language | eng | |
dc.publisher | Wiley-Blackwell Publishing, Inc | |
dc.relation | Reproduction in Domestic Animals | |
dc.relation | 1.422 | |
dc.relation | 0,594 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Effects of Short-term Hyper- and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and -Thyroid Axis and on Semen Quality in Male Beagles | |
dc.type | Artículos de revistas | |