Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributorFED UNIV PARA
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:29:28Z
dc.date.available2014-05-20T15:29:28Z
dc.date.created2014-05-20T15:29:28Z
dc.date.issued1996-10-01
dc.identifierPlanta Medica. Stuttgart: Georg Thieme Verlag, v. 62, n. 5, p. 402-404, 1996.
dc.identifier0032-0943
dc.identifierhttp://hdl.handle.net/11449/39058
dc.identifier10.1055/s-2006-957925
dc.identifierWOS:A1996VQ03600004
dc.description.abstractThe anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD(50) of t-DCTN was 555.0 mg/kg (p.o.) for mice.
dc.languageeng
dc.publisherGeorg Thieme Verlag
dc.relationPlanta Medica
dc.relation2.494
dc.relation0,581
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCroton cajucara
dc.subjectEuphorbiaceae
dc.subjecttrans-dehydrocrotonin
dc.subject19-nor-clerodane diterpene
dc.subjectanti-inflammatory and antinociceptive
dc.titleInvestigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.
dc.typeArtículos de revistas


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