dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T15:28:42Z | |
dc.date.available | 2014-05-20T15:28:42Z | |
dc.date.created | 2014-05-20T15:28:42Z | |
dc.date.issued | 2001-02-21 | |
dc.identifier | Cytokine. Philadelphia: W B Saunders Co, v. 13, n. 4, p. 248-252, 2001. | |
dc.identifier | 1043-4666 | |
dc.identifier | http://hdl.handle.net/11449/38455 | |
dc.identifier | 10.1006/cyto.2000.0824 | |
dc.identifier | WOS:000167421500009 | |
dc.identifier | 0000-0002-8059-0826 | |
dc.description.abstract | Patients with paracoccidioidomycosis (PCM) display a certain degree of immunecompromise characterized by lymphocyte hyporesponsiveness to the main Paracoccidioides brasiliensis antigen (gp43). To determine whether cytokines are involved in this state, we evaluated the secretion of IL-2, IL-10 and IFN-gamma by peripheral blood mononuclear cells (PBMC) from patients with the acute (AF) and chronic (CF) forms of PCM and from healthy, P. brasiliensis-sensitized subjects. gp43-stimulated PBMC from healthy subjects produced substantial amounts of IL-2, IFN-gamma and IL-10, whereas PBMC from AF and CF patients produced low levels of IL-2 and IFN-gamma but substantial amounts of IL-10, Phytohaemagglutinin-induced cytokine secretion was comparable among AF and CF patients and healthy subjects, suggesting integrity of non-specific cellular immune mechanisms in PCM. gp43-pulsed adherent cells, but not non-adherent cells, mere the main source of IL-10, Moreover, IL-2 and IFN-gamma secretion correlated inversely with the amount of specific antibodies produced by patients and healthy subjects. Our results suggest that the imbalance in cytokine production of patients with PCM plays a role in the gp43-hyporesponsiveness and the marked (non-protective) antibody production of these patients. (C) 2001 Academic Press. | |
dc.language | eng | |
dc.publisher | W B Saunders Co | |
dc.relation | Cytokine | |
dc.relation | 3.514 | |
dc.relation | 1,433 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | IL-2 | |
dc.subject | IL-10 | |
dc.subject | IFN-gamma | |
dc.subject | paracoccidioidomycosis | |
dc.subject | Paracoccidioides brasiliensis | |
dc.title | Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis | |
dc.type | Artículos de revistas | |