dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Estadual de Campinas (UNICAMP) | |
dc.contributor | Univ Estadual Ponta Grossa | |
dc.date.accessioned | 2014-05-20T15:28:06Z | |
dc.date.available | 2014-05-20T15:28:06Z | |
dc.date.created | 2014-05-20T15:28:06Z | |
dc.date.issued | 2002-04-01 | |
dc.identifier | Biological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 25, n. 4, p. 452-456, 2002. | |
dc.identifier | 0918-6158 | |
dc.identifier | http://hdl.handle.net/11449/37988 | |
dc.identifier | 10.1248/bpb.25.452 | |
dc.identifier | WOS:000174690200010 | |
dc.identifier | WOS000174690200010.pdf | |
dc.identifier | 3814504901386844 | |
dc.identifier | 0000-0002-8645-3777 | |
dc.description.abstract | The nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonin were compared with those obtained with another diterpene, DHC (trans-dehydrocrotonin) in the same models. When previously administered (p.o.) at the dose of 100 mg/kg, crotonin, as well as DHC, significantly reduced (p<0.05) gastric injury induced by stress (72, 67%), indomethacin/bethanechol (78, 29%) and pylorus ligature (35, 30%). In the HCl/ethanol-induced gastric ulcer model, at oral doses of 100 and 250 mg/kg, crotonin significantly prevented (p<0.05) the formation of gastric lesions by 51 and 56%, respectively, when compared to the control group. Gastric injury was also of significantly less magnitude in the DHC treatment group (p<0.05). In the pylorus-ligature model, crotonin (p.o.), like cimetidine, increased the volume of gastric juice when compared to the control group (p<0.05). No significant modifications where found in gastric parameters such as pH or total acid content after oral crotonin treatment. However, systemic alterations were observed when crotonin (100 mg/kg) was previously administered intraduodenally to mice. We observed significant changes (p<0.001) in gastric-juice parameters such as an increase in volume and a decrease in gastric acidity. Those pre-treated with crotonin as well as with DHC did not increase free mucus production (p>0.05). The results suggest that crotonin presents a significant anti-ulcer effect when assessed in these ulcer-induced models. As with DHC, the antiulcerogenic effects of crotonin are probably related to anti-secretory or/and gastroprotective properties of this substance. In light of results obtained with DHC and natural trans-crotonin in the present study, we concluded that the A-ring of both diterpenes is not directly involved in the antiulcerogenic activity. | |
dc.language | eng | |
dc.publisher | Pharmaceutical Soc Japan | |
dc.relation | Biological & Pharmaceutical Bulletin | |
dc.relation | 1.694 | |
dc.relation | 0,626 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | crotonin DHC | |
dc.subject | gastroprotective activity | |
dc.subject | Croton cajucara | |
dc.subject | diterpene | |
dc.subject | Euphorbiaceae | |
dc.title | Natural trans-crotonin: the antiulcerogenic effect of another diterpene isolated from the bark of Croton cajucara Benth. | |
dc.type | Artículos de revistas | |