dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Univ Texas | |
dc.date.accessioned | 2014-05-20T15:27:16Z | |
dc.date.available | 2014-05-20T15:27:16Z | |
dc.date.created | 2014-05-20T15:27:16Z | |
dc.date.issued | 2005-01-01 | |
dc.identifier | Journal of Dental Research. Alexandria: Int Amer Associação Dental Researchi A D R/a A D R, v. 84, n. 1, p. 79-83, 2005. | |
dc.identifier | 0022-0345 | |
dc.identifier | http://hdl.handle.net/11449/37281 | |
dc.identifier | 10.1177/154405910508400114 | |
dc.identifier | WOS:000226834000014 | |
dc.identifier | 8905977598945667 | |
dc.description.abstract | Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), the major dentin proteins, have been shown to induce neutrophil migration through release of IL-1beta, TNF-alpha, MIP-2, and KC. However, the sources of these mediators were not determined. Here, the roles of macrophages and mast cells (MC) in dentin-induced neutrophil accumulation were investigated. Peritoneal MC depletion or the enhancement of macrophage population increased DSP- and DPP-induced neutrophil extravasation. Moreover, supernatants from DSP- and DPP-stimulated macrophages caused neutrophil migration. The release of neutrophil chemotactic factor by macrophages was inhibited by dexamethasone or the supernatant of DSP- treated MC. Consistently, dexamethasone and the MC supernatant inhibited the production of IL-1beta, TNF-alpha, and MIP-2 by macrophages. This inhibitory activity of the DSP- stimulated MC was neutralized by anti-IL-4 and anti-IL-10 antibodies. These results indicate that dentin induces the release of the neutrophil chemotactic substance(s) by macrophages, which are down-modulated by MC-derived IL-4 and IL-10. | |
dc.language | eng | |
dc.publisher | Int Amer Assoc Dental Researchi | |
dc.relation | Journal of Dental Research | |
dc.relation | 5.380 | |
dc.relation | 2,302 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | neutrophil chemotaxis | |
dc.subject | DSP | |
dc.subject | DPP | |
dc.title | Macrophages and mast cells control the neutrophil migration induced by dentin proteins | |
dc.type | Artículos de revistas | |