Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributorUniv Costa Rica
dc.date.accessioned2014-05-20T15:27:14Z
dc.date.available2014-05-20T15:27:14Z
dc.date.created2014-05-20T15:27:14Z
dc.date.issued2004-12-01
dc.identifierBiochimica Et Biophysica Acta-proteins and Proteomics. Amsterdam: Elsevier B.V., v. 1703, n. 1, p. 83-85, 2004.
dc.identifier1570-9639
dc.identifierhttp://hdl.handle.net/11449/37254
dc.identifier10.1016/j.bbapap.2004.08.009
dc.identifierWOS:000225621800010
dc.identifier9162508978945887
dc.identifier0000-0003-2460-1145
dc.description.abstractSuramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA(2) from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 degreesC. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a=49.05, b=63.84 and c=85.67 Angstrom, Diffraction data was collected to 1.78 Angstrom. (C) 2004 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationBiochimica et Biophysica Acta: Proteins and Proteomics
dc.relation2.609
dc.relation1,170
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsuramin
dc.subjectmyotoxicity
dc.subjectsnake venom
dc.subjectLys49 PLA(2)s
dc.subjectX-ray diffraction
dc.titleCrystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom
dc.typeArtículos de revistas


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