dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:25:12Z
dc.date.available2014-05-20T15:25:12Z
dc.date.created2014-05-20T15:25:12Z
dc.date.issued1997-10-01
dc.identifierComparative Biochemistry and Physiology C-pharmacology Toxicology & Endocrinology. Oxford: Pergamon-Elsevier B.V., v. 118, n. 2, p. 241-245, 1997.
dc.identifier0742-8413
dc.identifierhttp://hdl.handle.net/11449/35650
dc.identifier10.1016/S0742-8413(97)00133-3
dc.identifierWOS:A1997YJ80900019
dc.description.abstractThe aim of the present study was to investigate the effects of perinatal estrogen exposure in the fertility of rats. Thus, rats were treated with estrogen on the 21st or 22nd day of intra-uterine life or treated with estrogen immediately after birth. It was observed that the testicular descent of males and beginning of puberty of females were advanced in all estrogen-treated groups. The females from estrogen-treated groups showed reduced frequency of estrous in 15 consecutive days of study, and there was an increase in estrous duration. Their fertility also were impaired and a reduction in the number of alive fetuses, as well as enhancement of pre- and postimplantation loss, mainly in the group treated with estrogen on the 21st day of intra-uterine life. However, the alterations observed in the fertility of estrogen-treated male rats were slighter and only females mated with male rats from the group treated with estrogen immediately after birth showed enhanced preimplantation loss. We suggest that the reproductive function is impaired by exposure to estrogen in the perinatal life of rats, and that the mechanisms involved in this effect are distinct for males and females. (C) 1997 Elsevier B.V.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationComparative Biochemistry and Physiology C-pharmacology Toxicology & Endocrinology
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectestrogen
dc.subjectfertility
dc.subjecthypothalamic differentiation
dc.subjectintrauterine life
dc.subjectperinatal life
dc.subjectrat
dc.subjectreproduction
dc.subjectsexual differentiation
dc.titlePerinatal estrogen exposure: Later repercussion on the fertility of rats
dc.typeArtículos de revistas


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