Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

dc.contributorVirginia Polytech Inst & State Univ
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorSmithKline Beecham Pharmaceut
dc.contributorUniv Addis Ababa
dc.date.accessioned2014-05-20T15:24:52Z
dc.date.available2014-05-20T15:24:52Z
dc.date.created2014-05-20T15:24:52Z
dc.date.issued1998-02-01
dc.identifierJournal of Natural Products. Washington: Amer Chemical Soc, v. 61, n. 2, p. 179-184, 1998.
dc.identifier0163-3864
dc.identifierhttp://hdl.handle.net/11449/35394
dc.identifier10.1021/np9701687
dc.identifierWOS:000072377000002
dc.identifier4484083685251673
dc.description.abstractBioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5),and Tr-B (7) and the novel seco-A protolimonoid 8. of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, C-13 NMR spectral assignments, and biological activities of:these compounds are reported.
dc.languageeng
dc.publisherAmer Chemical Soc
dc.relationJournal of Natural Products
dc.relation3.885
dc.relation1,368
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleLimonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica
dc.typeArtículos de revistas


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