dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Tufts Univ | |
dc.date.accessioned | 2014-05-20T15:24:47Z | |
dc.date.available | 2014-05-20T15:24:47Z | |
dc.date.created | 2014-05-20T15:24:47Z | |
dc.date.issued | 2007-09-01 | |
dc.identifier | Free Radical Biology and Medicine. New York: Elsevier B.V., v. 43, n. 5, p. 740-751, 2007. | |
dc.identifier | 0891-5849 | |
dc.identifier | http://hdl.handle.net/11449/35327 | |
dc.identifier | 10.1016/j.freeradbiomed.2007.05.002 | |
dc.identifier | WOS:000248679500010 | |
dc.identifier | 2940051650846541 | |
dc.identifier | 6309835137998766 | |
dc.identifier | 6990977122340795 | |
dc.description.abstract | The mechanism of doxorubicin-induced cardiotoxicity remains controversial. Wistar rats (n=96) were randomly assigned to a control (C), lycopene (L), doxorubicin (D), or doxorubicin+lycopene (DL) group. The L and DL groups received lycopene (5 mg/kg body wt/day by gavage) for 7 weeks. The D and DL groups received doxombicin (4 mg/kg body wt intraperitoneally) at 3, 4, 5, and 6 weeks and were killed at 7 weeks for analyses. Myocardial tissue lycopene levels and total antioxidant performance (TAP) were analyzed by HPLC and fluorometry, respectively. Lycopene metabolism was determined by incubating H-2(10)-lycopene with intestinal mucosa postmitochondrial fraction and lipoxygenase and analyzed with HPLC and APCI mass spectroscopy. Myocardial tissue lycopene levels in DL and L were similar. TAP adjusted for tissue protein were higher in myocardium of D than those of C (P=0.002). Lycopene metabolism study identified a lower oxidative cleavage of lycopene in D as compared to those of C. Our results showed that lycopene was not depleted in myocardium of lycopene-supplemented rats treated with doxorubicin and that higher antioxidant capacity in myocardium and less oxidative cleavage of lycopene in intestinal mucosa of doxorubicin-treated rats suggest an antioxidant role of doxombicin rather than acting as a prooxidant. (c) 2007 Elsevier B.V. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Free Radical Biology and Medicine | |
dc.relation | 6.020 | |
dc.relation | 2,178 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | lycopene | |
dc.subject | doxorubicin | |
dc.subject | heart | |
dc.subject | rat | |
dc.subject | enzymatic cleavage | |
dc.subject | oxidative cleavage | |
dc.subject | antioxidant capacity | |
dc.title | Doxorubicin as an antioxidant: Maintenance of myocardial levels of lycopene under doxorubicin treatment | |
dc.type | Artículos de revistas | |