dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorTufts Univ
dc.date.accessioned2014-05-20T15:24:47Z
dc.date.available2014-05-20T15:24:47Z
dc.date.created2014-05-20T15:24:47Z
dc.date.issued2007-09-01
dc.identifierFree Radical Biology and Medicine. New York: Elsevier B.V., v. 43, n. 5, p. 740-751, 2007.
dc.identifier0891-5849
dc.identifierhttp://hdl.handle.net/11449/35327
dc.identifier10.1016/j.freeradbiomed.2007.05.002
dc.identifierWOS:000248679500010
dc.identifier2940051650846541
dc.identifier6309835137998766
dc.identifier6990977122340795
dc.description.abstractThe mechanism of doxorubicin-induced cardiotoxicity remains controversial. Wistar rats (n=96) were randomly assigned to a control (C), lycopene (L), doxorubicin (D), or doxorubicin+lycopene (DL) group. The L and DL groups received lycopene (5 mg/kg body wt/day by gavage) for 7 weeks. The D and DL groups received doxombicin (4 mg/kg body wt intraperitoneally) at 3, 4, 5, and 6 weeks and were killed at 7 weeks for analyses. Myocardial tissue lycopene levels and total antioxidant performance (TAP) were analyzed by HPLC and fluorometry, respectively. Lycopene metabolism was determined by incubating H-2(10)-lycopene with intestinal mucosa postmitochondrial fraction and lipoxygenase and analyzed with HPLC and APCI mass spectroscopy. Myocardial tissue lycopene levels in DL and L were similar. TAP adjusted for tissue protein were higher in myocardium of D than those of C (P=0.002). Lycopene metabolism study identified a lower oxidative cleavage of lycopene in D as compared to those of C. Our results showed that lycopene was not depleted in myocardium of lycopene-supplemented rats treated with doxorubicin and that higher antioxidant capacity in myocardium and less oxidative cleavage of lycopene in intestinal mucosa of doxorubicin-treated rats suggest an antioxidant role of doxombicin rather than acting as a prooxidant. (c) 2007 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationFree Radical Biology and Medicine
dc.relation6.020
dc.relation2,178
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectlycopene
dc.subjectdoxorubicin
dc.subjectheart
dc.subjectrat
dc.subjectenzymatic cleavage
dc.subjectoxidative cleavage
dc.subjectantioxidant capacity
dc.titleDoxorubicin as an antioxidant: Maintenance of myocardial levels of lycopene under doxorubicin treatment
dc.typeArtículos de revistas


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