Myelodysplastic syndrome in childhood: report of two cases with deletion of chromosome 4 and the Philadelphia chromosome

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:20:35Z
dc.date.available2014-05-20T15:20:35Z
dc.date.created2014-05-20T15:20:35Z
dc.date.issued2002-06-01
dc.identifierLeukemia Research. Oxford: Pergamon-Elsevier B.V., v. 26, n. 6, p. 533-538, 2002.
dc.identifier0145-2126
dc.identifierhttp://hdl.handle.net/11449/31858
dc.identifier10.1016/S0145-2126(01)00152-7
dc.identifierWOS:000175972700003
dc.description.abstractWe report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. The cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at different moments of the disease. One patient showed the Ph chromosome at disease transformation and the other at diagnosis. The different breakpoints at 4q and the presence of Ph could be a marker of this form of MDS. The association of clinical and hematological findings suggests the possibility of a new group of pediatric MDS. (C) 2002 Elsevier B.V. Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationLeukemia Research
dc.relation2.319
dc.relation1,063
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmyelodysplastic syndrome
dc.subjectPhiladelphia chromosome
dc.subjectchromosome 4
dc.subjectdeletion
dc.subjectcytogenetic
dc.subjectFAB group
dc.titleMyelodysplastic syndrome in childhood: report of two cases with deletion of chromosome 4 and the Philadelphia chromosome
dc.typeArtículos de revistas


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