CENTRAL ANGIOTENSIN-CONVERTING ENZYME-BLOCKADE AND THIRST

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:20:08Z
dc.date.available2014-05-20T15:20:08Z
dc.date.created2014-05-20T15:20:08Z
dc.date.issued1993-09-01
dc.identifierBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 26, n. 9, p. 999-1007, 1993.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/31477
dc.identifierWOS:A1993LY94100012
dc.identifier1023597870118105
dc.identifier6551236936295697
dc.description.abstract1. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g).2. Injection of lisinopril (2 mug/mul) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100%) and water deprivation (90%) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60%). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group).3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.relation1.492
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectWATER INTAKE
dc.subjectDEHYDRATION
dc.subjectHYPOVOLEMIA
dc.subjectANGIOTENSIN-II
dc.subjectLISINOPRIL
dc.subjectMEDIAL PREOPTIC AREA
dc.titleCENTRAL ANGIOTENSIN-CONVERTING ENZYME-BLOCKADE AND THIRST
dc.typeArtículos de revistas


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