Flow-injection spectrophotometric determination of methyldopa in pharmaceutical formulations

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:20:06Z
dc.date.available2014-05-20T15:20:06Z
dc.date.created2014-05-20T15:20:06Z
dc.date.issued2005-07-15
dc.identifierTalanta. Amsterdam: Elsevier B.V., v. 67, n. 1, p. 240-244, 2005.
dc.identifier0039-9140
dc.identifierhttp://hdl.handle.net/11449/31450
dc.identifier10.1016/j.talanta.2005.03.001
dc.identifierWOS:000230528500032
dc.identifier5978908591853524
dc.identifier3192125098361121
dc.identifier0000-0003-0197-7369
dc.description.abstractA flow-injection spectrophotometric procedure is proposed for methyldopa determination in pharmaceutical preparations. The determination is based on formation of a yellow product (measured at 410 nm) after complexation of methyldopa with molybdate. Under optimal conditions, Beer's law is obeyed in a concentration range of 50-200 mg l(-1) methyldopa. Typical correlation between absorbance and analyte concentration was 0.9999. Usual excipients used as additives in pharmaceuticals do not interfere with the proposed method. The analytical frequency was 210 h(-1) and the relative standard deviation (R.S.D.) was <= 2% for sample solution containing 150 mg l(-1) methyldopa (n = 11). The analytical results obtained in commercial formulations by applying the proposed FIA method were in good agreement with labeled values and those obtained by the Brazilian Pharmacopoeia procedure at 95% confidence level. (C) 2005 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationTalanta
dc.relation4.244
dc.relation1,186
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectflow-injection analysis
dc.subjectmethyldopa
dc.subjectmolybdate
dc.subjectpharmaceutical formulations
dc.titleFlow-injection spectrophotometric determination of methyldopa in pharmaceutical formulations
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución