Antibacterial activity of labdane diterpenoids from Stemodia foliosa

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal Rural de Pernambuco (UFRPE)
dc.contributorUniversidade Federal de Pernambuco (UFPE)
dc.date.accessioned2014-05-20T14:20:14Z
dc.date.available2014-05-20T14:20:14Z
dc.date.created2014-05-20T14:20:14Z
dc.date.issued2008-07-01
dc.identifierJournal of Natural Products. Washington: Amer Chemical Soc, v. 71, n. 7, p. 1291-1293, 2008.
dc.identifier0163-3864
dc.identifierhttp://hdl.handle.net/11449/26081
dc.identifier10.1021/np800106x
dc.identifierWOS:000257953800036
dc.identifier1308042794786872
dc.description.abstractAs part of a continuing interest in exploring the chemistry of Brazilian medicinal plants, three new labdane diterpenoids, 6 alpha-acetoxymanoyl oxide (1), 6 alpha-malonyloxymanoyl oxide (2), and 6 alpha-malonyloxy-n-butyl ester manoyl oxide (3), together with the known betulinic acid, lupeol, sitosterol, and stigmasterol, were isolated from the aerial parts of Stemodia foliosa. The structures of 1-3 were established on the basis of interpretation of spectroscopic data, including HRESIMS, and 1D and 2D NMR techniques. All compounds were tested against a bacteria panel consisting of Staphylococcus aureus, Bacillus cereus, B. subtilis, B. anthracis, Micrococcus luteus, Mycobacterium smegmatis, and M. phlei. Compound 2 showed, moderate activity against these strains, with MIC values in the range 7-20 mu g/mL.
dc.languageeng
dc.publisherAmer Chemical Soc
dc.relationJournal of Natural Products
dc.relation3.885
dc.relation1,368
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleAntibacterial activity of labdane diterpenoids from Stemodia foliosa
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución