dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal do Ceará (UFC)
dc.contributorInstituto Agronômico (IAC)
dc.date.accessioned2014-05-20T14:20:12Z
dc.date.available2014-05-20T14:20:12Z
dc.date.created2014-05-20T14:20:12Z
dc.date.issued2009-10-01
dc.identifierJournal of Natural Products. Washington: Amer Chemical Soc, v. 72, n. 10, p. 1847-1850, 2009.
dc.identifier0163-3864
dc.identifierhttp://hdl.handle.net/11449/26065
dc.identifier10.1021/np9004079
dc.identifierWOS:000271950400019
dc.description.abstractA crude bioactive EtOH extract of the twigs of Casearia obliqua afforded two new clerodane diterpenes, caseobliquins A (1) and B (2). Additionally, bioactivity-directed fractionation on a bioactive hexane extract of the leaves from this species led. to the isolation of the known clerodane diterpenes rel-6 beta-hydroxyzuelanin-2 beta-benzoate and rel-2 alpha-hydroxyzuelanin-6 beta-benzoate (3 and 4) as a mixture and 2 beta-hydroxyzuelanin-6 beta-cinnamate (5). The structures of the new clerodanes 1 and 2 were established on the basis of their 1D and 2D NMR spectroscopic data, and the new compound I and the known substance 5 had their absolute configurations determined by circular dichroism spectroscopy. The cytotoxicity of several of the compounds isolated was evaluated against a small panel of human tumor cell lines.
dc.languageeng
dc.publisherAmer Chemical Soc
dc.relationJournal of Natural Products
dc.relation3.885
dc.relation1,368
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleCytotoxic Clerodane Diterpenoids from Casearia obliqua
dc.typeArtículos de revistas


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