dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Federal do Ceará (UFC) | |
dc.contributor | Instituto Agronômico (IAC) | |
dc.date.accessioned | 2014-05-20T14:20:12Z | |
dc.date.available | 2014-05-20T14:20:12Z | |
dc.date.created | 2014-05-20T14:20:12Z | |
dc.date.issued | 2009-10-01 | |
dc.identifier | Journal of Natural Products. Washington: Amer Chemical Soc, v. 72, n. 10, p. 1847-1850, 2009. | |
dc.identifier | 0163-3864 | |
dc.identifier | http://hdl.handle.net/11449/26065 | |
dc.identifier | 10.1021/np9004079 | |
dc.identifier | WOS:000271950400019 | |
dc.description.abstract | A crude bioactive EtOH extract of the twigs of Casearia obliqua afforded two new clerodane diterpenes, caseobliquins A (1) and B (2). Additionally, bioactivity-directed fractionation on a bioactive hexane extract of the leaves from this species led. to the isolation of the known clerodane diterpenes rel-6 beta-hydroxyzuelanin-2 beta-benzoate and rel-2 alpha-hydroxyzuelanin-6 beta-benzoate (3 and 4) as a mixture and 2 beta-hydroxyzuelanin-6 beta-cinnamate (5). The structures of the new clerodanes 1 and 2 were established on the basis of their 1D and 2D NMR spectroscopic data, and the new compound I and the known substance 5 had their absolute configurations determined by circular dichroism spectroscopy. The cytotoxicity of several of the compounds isolated was evaluated against a small panel of human tumor cell lines. | |
dc.language | eng | |
dc.publisher | Amer Chemical Soc | |
dc.relation | Journal of Natural Products | |
dc.relation | 3.885 | |
dc.relation | 1,368 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Cytotoxic Clerodane Diterpenoids from Casearia obliqua | |
dc.type | Artículos de revistas | |