Artículos de revistas
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Fecha
2011-06-01Registro en:
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 3, p. 456-464, 2011.
0102-695X
10.1590/S0102-695X2011005000061
S0102-695X2011000300017
WOS:000292919800017
S0102-695X2011000300017.pdf
9352141379363877
Autor
Universidade Estadual Paulista (Unesp)
Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Federal do Ceará (UFC)
Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP)
Institución
Resumen
Cytotoxic activity of eight plant extracts, native from the Mid-West of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL-1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL-1) was used as the positive control and the MTT method was used to detect the activity. Cytotoxicity of distinct polarities was observed in thirty extracts (46%), from different parts of the following species: Tabebuia heptaphylla (Vell.) Toledo, Bignoniaceae, Tapirira guianensis Aubl., Anacardiaceae, Myracrodruon urundeuva Allemão, Anacardiaceae, Schinus terebinthifolius Raddi, Anacardiaceae, Gomphrena elegans Mart., Amaranthaceae, Attalea phalerata Mart. ex Spreng., Arecaceae, Eugenia uniflora L., Myrtaceae, and Annona dioica A. St.-Hil., Annonaceae. Extracts of at least two tested cell strains were considered to be highly active since their inhibition rate was over 75%.