Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T14:18:55Z
dc.date.available2014-05-20T14:18:55Z
dc.date.created2014-05-20T14:18:55Z
dc.date.issued2010-01-01
dc.identifierQuímica Nova. Sociedade Brasileira de Química, v. 33, n. 4, p. 964-967, 2010.
dc.identifier0100-4042
dc.identifierhttp://hdl.handle.net/11449/25697
dc.identifier10.1590/S0100-40422010000400036
dc.identifierS0100-40422010000400036
dc.identifierWOS:000278322500036
dc.identifierS0100-40422010000400036.pdf
dc.identifier1923726000036625
dc.description.abstractAn analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed. After the optimization of the experimental conditions, calibration curves were obtained in the linear concentration range from 9.78 × 10-7 to 7.25 × 10-5 mol L-1 resulting in a limit of detection of 2.12 ± 0.05 x 10-8 mol L-1. Statistical tests showed that the concentrations of 5-ASA in commercial tablets and enemas obtained with the proposed voltammetric method agreed with HPLC values at a 95% confidence level.
dc.languageeng
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.relation0.646
dc.relation0,255
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subject5-aminosalicylic acid
dc.subjectpharmaceutical formulations
dc.subjectpencil graphite electrode
dc.titleDetermination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes
dc.typeArtículos de revistas


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