Artículos de revistas
Peptídeos cíclicos de biomassa vegetal: características, diversidade, biossíntese e atividades biológicas
Fecha
2009-01-01Registro en:
Química Nova. Sociedade Brasileira de Química, v. 32, n. 5, p. 1262-1277, 2009.
0100-4042
10.1590/S0100-40422009000500033
S0100-40422009000500033
WOS:000269124800033
S0100-40422009000500033.pdf
4484083685251673
9424346762460416
0000-0002-4767-0904
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Natural peptides are outstanding as the most promising macromolecules in the search for new drugs, especially those of cyclic nature. The higher plants revealed a very peculiar composition of their cyclic peptides, which distinguish themselves by a head-to-tail cyclization. It is possible to define two groups of cyclic peptides from plant biomass. Those called in this review as Eucyclopeptides formed by 2-12 amino acid, and Cyclotides considered as circular polypeptides, composed of 29-37 amino acid that retain three disulfides bridges in an arrangement known as cyclic cystine knot. Searching for plant peptides should form into a subject for scientific research in the forefront of great importance for bioprospecting natural products macromolecular.