Highly Sensitive Neurotransmitters Analysis at Platinum-Ultramicroelectrodes Arrays

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:53:34Z
dc.date.available2014-05-20T13:53:34Z
dc.date.created2014-05-20T13:53:34Z
dc.date.issued2012-05-01
dc.identifierElectroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 24, n. 5, p. 1115-1120, 2012.
dc.identifier1040-0397
dc.identifierhttp://hdl.handle.net/11449/19119
dc.identifier10.1002/elan.201200011
dc.identifierWOS:000303439500018
dc.identifier7781282422851911
dc.description.abstractAn easy way to determine norepinephrine (NE) in biological fluid using a platinum ultramicroelectrode array (Pt-UMEAs) is described. Issues related to UME electrode surface treatment and characterizations are also addressed. At optimized experimental conditions the dynamic concentration range was 1.0 to 10.0 mu mol?L-1 with a detection limit of 40.5 nmol?L-1. The repeatability of current responses for injections of 5 mu mol?L-1 NE was evaluated to be 4.0?% (n=10). This approach obtained excellent sensitivity, a reliable calibration profile and stable electrochemical response for norepinephrine detection. The content of NE in urine samples without any preconcentration, purification, or pretreatment step, was successfully analyzed by the standard addition method using the Pt-UMEAs.
dc.languageeng
dc.publisherWiley-v C H Verlag Gmbh
dc.relationElectroanalysis
dc.relation2.851
dc.relation0,692
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPlatinum ultramicroelectrode array
dc.subjectNorepinephrine
dc.subjectBiological fluids
dc.titleHighly Sensitive Neurotransmitters Analysis at Platinum-Ultramicroelectrodes Arrays
dc.typeArtículos de revistas


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