dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:51:04Z
dc.date.available2014-05-20T13:51:04Z
dc.date.created2014-05-20T13:51:04Z
dc.date.issued2009-01-01
dc.identifierNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 23, n. 16, p. 1552-1558, 2009.
dc.identifier1478-6419
dc.identifierhttp://hdl.handle.net/11449/18236
dc.identifier10.1080/14786410902809328
dc.identifierWOS:000273303000012
dc.description.abstractAlthough clove possesses several biological and therapeutic properties, its immunomodulatory action has not been fully investigated. The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production. After treatment, spleen cells were aseptically removed and cells were stimulated with concanavalin A. Supernatants of cell cultures were used for cytokine determination by ELISA. The chemical composition of the extract was also carried out, revealing that eugenol(4-allyl-2-methoxyphenol) was the major component in our sample. Although the anti-inflammatory action of clove has been mentioned, our data showed that clove administration to mice did not influence the Th1/Th2 cytokine balance. Further studies dealing with cytokine expression and production will provide a better understanding of clove's immunomodulatory and anti-inflammatory actions, using different extract concentrations and different intake periods.
dc.languageeng
dc.publisherTaylor & Francis Ltd
dc.relationNatural Product Research
dc.relation1.928
dc.relation0,671
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectclove
dc.subjectcytokines
dc.subjectspleen cells
dc.subjectimmunomodulation
dc.titleTh1/Th2 cytokine production by clove-treated mice
dc.typeArtículos de revistas


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