dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Estadual de Campinas (UNICAMP) | |
dc.date.accessioned | 2014-05-20T13:49:52Z | |
dc.date.available | 2014-05-20T13:49:52Z | |
dc.date.created | 2014-05-20T13:49:52Z | |
dc.date.issued | 2009-03-01 | |
dc.identifier | Molecules. Basel: Molecular Diversity Preservation International-mdpi, v. 14, n. 3, p. 1098-1110, 2009. | |
dc.identifier | 1420-3049 | |
dc.identifier | http://hdl.handle.net/11449/17790 | |
dc.identifier | 10.3390/molecules14031098 | |
dc.identifier | WOS:000264565000016 | |
dc.identifier | WOS000264565000016.pdf | |
dc.identifier | 3538253640602977 | |
dc.identifier | 3814504901386844 | |
dc.identifier | 0000-0002-8645-3777 | |
dc.identifier | 0000-0003-3032-2556 | |
dc.description.abstract | This study was designed to determine the gastroprotective effect of a Mangifera indica leaf decoction (AD), on different experimental models in rodents. The administration of AD up to a dose of 5 g/kg (p.o.) did not produce any signs or symptoms of toxicity in the treated animals, while significantly decreasing the severity of gastric damage induced by several gastroprotective models. Oral pre-treatment with AD ( 250, 500 or 1000 mg/kg) in mice and rats with gastric lesions induced by HCl/ethanol, absolute ethanol, non-steroidal anti-inflammatory drug (NSAID) or stress-induced gastric lesions resulted in a significant decrease of said lesions. Phytochemical analyses of AD composition demonstrated the presence of bioactive phenolic compounds that represent 57.3% of total phenolic content in this extract. Two main phenolic compounds were isolated, specifically mangiferin (C-glucopyranoside of 1,3,6,7-tetrahydroxyxanthone) and C-glucosylbenzophenone (3-C-beta-D-glucopyranosyl-4',2,4,6-tetrahydroxybenzophenone). These findings indicate the potential gastroprotective properties of aqueous decoction from M. indica leaves. | |
dc.language | eng | |
dc.publisher | Molecular Diversity Preservation International-mdpi | |
dc.relation | Molecules | |
dc.relation | 3.098 | |
dc.relation | 0,855 | |
dc.rights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | Mangifera indica | |
dc.subject | Antiulcer gastric | |
dc.subject | Mangiferin | |
dc.subject | Benzophenone | |
dc.subject | Phenolic compounds | |
dc.title | Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.) | |
dc.type | Artículos de revistas | |