dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:49:46Z
dc.date.available2014-05-20T13:49:46Z
dc.date.created2014-05-20T13:49:46Z
dc.date.issued2006-03-08
dc.identifierJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 104, n. 1-2, p. 207-214, 2006.
dc.identifier0378-8741
dc.identifierhttp://hdl.handle.net/11449/17754
dc.identifier10.1016/j.jep.2005.09.002
dc.identifierWOS:000236085600032
dc.identifier0019393779801069
dc.identifier3538253640602977
dc.identifier3814504901386844
dc.identifier0000-0002-8645-3777
dc.identifier0000-0003-3032-2556
dc.identifier0000-0002-4494-4180
dc.description.abstractQualea grandiflora is one of the species widely used in folk medicine to treat gastric ulcers in Cerrado of the central region of Brazil. The hydroalcoholic extract of bark (HE) of Qualea grandiflora was investigated for their ability to prevent and heal lesions in the gastric mucosa. The oral administration of HE exhibited antiulcer activity decreasing the ulcerative index induced by HCl/ethanol solution, indomethacin/bethanechol and stress. In the Shay model, results showed that HE (p.o.) only reduced the severity of gastric lesions without effects on pH, gastric acidity or volume. When given by intraduodenal route, HE changed the pH, but did not modify the other parameters of the gastric juice. These data were in accordance with those obtained when HE was administered orally for 14 days after gastric ulcers were induced by acetic acid in rats. HE presented healing process in subacute gastric ulcer induced by acetic acid in rats. Moreover, histological examinations showed the simple columnar epithelium, lamina propria with simple branched tubular glandules with dilated lumen and large amounts of mucus secretion. Phytochemical investigation of HE led to the detection of terpenes, steroids, saponins, phenolic compounds and tannins in this extract, which may be involved in the observed activity. (c) 2005 Elsevier B.V.. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal of Ethnopharmacology
dc.relation3.115
dc.relation1,150
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectQualea grandiflora
dc.subjectvochysiaceae
dc.subjectantiulcer effect
dc.subjecthealing activity
dc.subjectmedicinal plants
dc.subjectCerrado
dc.titleQualea grandiflora, a Brazilian Cerrado medicinal plant presents an important antiulcer activity
dc.typeArtículos de revistas


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