dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:45:45Z | |
dc.date.available | 2014-05-20T13:45:45Z | |
dc.date.created | 2014-05-20T13:45:45Z | |
dc.date.issued | 2002-03-22 | |
dc.identifier | Brain Research. Amsterdam: Elsevier B.V., v. 931, n. 1, p. 1-4, 2002. | |
dc.identifier | 0006-8993 | |
dc.identifier | http://hdl.handle.net/11449/16122 | |
dc.identifier | 10.1016/S0006-8993(01)03202-4 | |
dc.identifier | WOS:000174777100001 | |
dc.identifier | 1023597870118105 | |
dc.description.abstract | Calcium channels mediate the actions of many drugs. The present work investigated whether diltiazem, an L-type calcium channel blocker, alters the inhibition of sodium appetite induced by noradrenaline and the alpha(2)-adrenoceptor agonist clonidine. Adult male Holtzman rats (N=4-8) with cannula implanted into the third cerebral ventricle were submitted to sodium depletion {furosemide sc+24-h removal of ambiente sodium). Sodium depleted control animals that received 0.9% NaCl as vehicle injected intracerebroventricularly (i.c.v) ingested 13.0+/-1.5 ml/120 min of 1.8% NaCl. Intracerebroventricular injection of either noradrenaline (80 nmol) or clonidine (20 nmol) inhibited 1.8% NaCl intake from 70 to 90%. Prior i.c.v. injection of diltiazem (6-48 nmol) inhibited from 50 to 100% the effect of noradrenaline and clonidine in a dose-response manner. Diltiazem alone at 100 nmol inhibited, but at 50 nmol had no effect on, sodium appetite. The results suggest: (1) common ionic mechanisms involving calcium channels for the inhibition that noradrenaline and clonidine exert on sodium appetite and (2) a dual role for the benzothiazepine site of L-type calcium channels in the control of sodium appetite. (C) 2002 Elsevier B.V. B V. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Brain Research | |
dc.relation | 3.125 | |
dc.relation | 1,404 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | diltiazem | |
dc.subject | clonidine | |
dc.subject | noradrenaline | |
dc.subject | dehydration | |
dc.subject | sodium depletion | |
dc.subject | salt intake | |
dc.title | Interaction between brain L-type calcium channels and alpha(2)-adrenoceptors in the inhibition of sodium appetite | |
dc.type | Artículos de revistas | |