dc.contributor | Universidade Federal do Rio de Janeiro (UFRJ) | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Univ Anhembi Morumbi | |
dc.contributor | Ft Dodge Saúde Anim Ltda | |
dc.contributor | Ft Dodge Anim Hlth | |
dc.date.accessioned | 2014-02-26T17:23:07Z | |
dc.date.accessioned | 2014-05-20T13:44:33Z | |
dc.date.available | 2014-02-26T17:23:07Z | |
dc.date.available | 2014-05-20T13:44:33Z | |
dc.date.created | 2014-02-26T17:23:07Z | |
dc.date.created | 2014-05-20T13:44:33Z | |
dc.date.issued | 2005-09-23 | |
dc.identifier | Vaccine. Oxford: Elsevier B.V., v. 23, n. 40, p. 4805-4810, 2005. | |
dc.identifier | 0264-410X | |
dc.identifier | http://hdl.handle.net/11449/15622 | |
dc.identifier | 10.1016/j.vaccine.2005.05.011 | |
dc.identifier | WOS:000232218600001 | |
dc.description.abstract | Leishmune (R) vaccine is the first licensed vaccine against canine visceral leishmaniasis. It contains the Fucose-Mannose-ligand (FML) antigen of Leishmania donovani. The potential Leishmune (R) vaccine effect on the interruption of the transmission of the disease, was assayed by monitoring, in untreated (n = 40) and vaccinated dogs (n = 32) of a Brazilian epidemic area: the kala-azar clinical signs, the FML-seropositivity and the Leishmania parasite evidence by immunohistochemistry of skin and PCR for Leishmanial DNA of lymph node and blood samples. on month I I after vaccination, untreated controls showed: 25% of symptomatic cases, 50% of FML-seropositivity, 56.7% of lymph node PCR, 15.7% of blood PCR and 25% of immunohistochemical positive reactions. The Leishmune (R)-vaccinated dogs showed 100% of seropositivity to FML and a complete absence of clinical signs and of parasites (0%) in skin, lymph node and blood PCR samples (P < 0.01). The positivity in FML-ELISA in untreated dogs significantly correlates with the PCR in lymph node samples (p < 0.001) and with the increase in number of symptoms (p = 0.006) being strong markers of infectiousness. The absence of symptoms and of evidence of Leishmania DNA and parasites in Leishmune (R)-vaccinated animals indicates the non-infectious condition of the Leishmune (R)-vaccinated dogs. (c) 2005 Elsevier Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Vaccine | |
dc.relation | 3.285 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | canine visceral leishmaniasis | |
dc.subject | FML-vaccine | |
dc.subject | transmission blocking vaccines | |
dc.title | Leishmune (R) vaccine blocks the transmission of canine visceral leishmaniasis - Absence of Leishmania parasites in blood, skin and lymph nodes of vaccinated exposed dogs | |
dc.type | Artículos de revistas | |