Effects of fluoride intake on insulin sensitivity and insulin signal transduction

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:13Z
dc.date.accessioned2014-05-20T13:43:02Z
dc.date.available2013-09-30T18:29:13Z
dc.date.available2014-05-20T13:43:02Z
dc.date.created2013-09-30T18:29:13Z
dc.date.created2014-05-20T13:43:02Z
dc.date.issued2008-10-01
dc.identifierFluoride. Ocean View: Int Soc Fluoride Research, v. 41, n. 4, p. 270-275, 2008.
dc.identifier0015-4725
dc.identifierhttp://hdl.handle.net/11449/14977
dc.identifierWOS:000263901900003
dc.identifier7239471016654133
dc.identifier8275401688702343
dc.identifier4419158525709686
dc.identifier0000-0001-5069-8812
dc.description.abstractForty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues.
dc.languageeng
dc.publisherInt Soc Fluoride Research
dc.relationFluoride
dc.relation1.438
dc.relation0,429
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectInsulin receptor substrate
dc.subjectInsulin sensitivity
dc.subjectInsulin signal
dc.subjectPlasma fluoride
dc.subjectRats and insulin
dc.titleEffects of fluoride intake on insulin sensitivity and insulin signal transduction
dc.typeArtículos de revistas


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