dc.contributorBarretos Canc Hosp
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorAC Camargo Canc Treatment & Res Ctr
dc.date.accessioned2014-05-20T13:38:51Z
dc.date.available2014-05-20T13:38:51Z
dc.date.created2014-05-20T13:38:51Z
dc.date.issued2012-01-01
dc.identifierCancer Biomarkers. Amsterdam: IOS Press, v. 11, n. 5, p. 209-217, 2012.
dc.identifier1574-0153
dc.identifierhttp://hdl.handle.net/11449/13481
dc.identifier10.3233/CBM-2012-00281
dc.identifierWOS:000312001200004
dc.identifier2259986546265579
dc.identifier7528116925519142
dc.description.abstractIn the case of operated breast cancer (BC), prognostic markers help to determine if the patient needs additional treatment and predictive markers help the clinician to decide which treatment to use. Thus, a better knowledge of known predictive and prognostic markers and the identification of new markers, may improve the treatment of BC patients. The transforming growth factor-beta type II receptor (TGF-beta RII), a main receptor of transforming growth factor beta pathway, is a potential new prognostic marker. The aims of the present study were to investigate both the predictive and prognostic impact of TGF-beta RII in BC samples. TGF-beta RII protein expression was evaluated using immunohistochemistry on a tissue microarray containing 110 TNM stage III BC samples obtained prior to doxorubicin-based neoadjuvant chemotherapy (NAC). Our results demonstrate that TGF-beta RII did not predict the response to NAC. on the other hand, an association between TGF-beta RII-negative tumor and higher risk of metastasis to lungs and bones was verified. TGF-beta RII negativity was an independent prognostic factor for decreased disease-free and overall survival.
dc.languageeng
dc.publisherIOS Press
dc.relationCancer Biomarkers
dc.relation2.392
dc.relation0,826
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBreast cancer
dc.subjectsurvival
dc.subjectTGF-beta RII
dc.subjectmetastasis
dc.subjectprognostic marker
dc.titleAbsence of TGF-beta RII predicts bone and lung metastasis and is associated with poor prognosis in stage III breast tumors
dc.typeArtículos de revistas


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