The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorNorthwestern University (NU)
dc.contributorSanta Casa Faculty of Medicine of São Paulo
dc.date.accessioned2014-05-20T13:37:10Z
dc.date.available2014-05-20T13:37:10Z
dc.date.created2014-05-20T13:37:10Z
dc.date.issued2013-01-01
dc.identifierActa Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013.
dc.identifier0102-8650
dc.identifierhttp://hdl.handle.net/11449/12842
dc.identifier10.1590/S0102-86502013000100002
dc.identifierS0102-86502013000100002
dc.identifierWOS:000313866600001
dc.identifierS0102-86502013000100002.pdf
dc.identifier8223546475724058
dc.identifier7802830125342070
dc.identifier0585723113037140
dc.description.abstractPURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
dc.languageeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relationActa Cirúrgica Brasileira
dc.relation0.933
dc.relation0,395
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectAcute Kidney Injury
dc.subjectFluid Therapy
dc.subjectColloids
dc.subjectHetastarch
dc.subjectRats
dc.titleThe effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
dc.typeArtículos de revistas


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