dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:32:53Z
dc.date.available2014-05-20T13:32:53Z
dc.date.created2014-05-20T13:32:53Z
dc.date.issued2000-06-01
dc.identifierBasic Research In Cardiology. Darmstadt: Dr Dietrich Steinkopff Verlag, v. 95, n. 3, p. 208-214, 2000.
dc.identifier0300-8428
dc.identifierhttp://hdl.handle.net/11449/11244
dc.identifier10.1007/s003950050183
dc.identifierWOS:000087620900005
dc.identifier6990977122340795
dc.identifier6309835137998766
dc.identifier5016839015394547
dc.description.abstractBackground: ACE inhibitors have shown beneficial results in several studies after myocardial infarction (MI). However, these studies have shown conflicting results about the ideal starting time of the ACE inhibitors administration after MI and the importance of infarct size.Objectives: This study was designed to assess the long-term effects of lisinopril on mortality, cardiac function, and ventricular fibrosis after MI, in rats.Methods: Lisinopril (20 mg/kg/day) was given on day 1 or 21 days after coronary occlusion in small or large infarctions.Results: the mortality rate was reduced by 39% in early treatment and 30% in delayed treatment in comparison to the untreated rats. Early treatment reduced cardiac dysfunction in small MIs; however, delayed treatment did not. No statistical difference was observed among the groups for large MIs. No statistical difference was observed among the groups with large or small MIs on myocardial hydroxyproline concentration.Conclusions: Both early and delayed treatments with lisinopril increased survival. Treatment exerts no marked effects on fibrosis; early treatment has exerted beneficial influences on cardiac function whereas delayed treatment had no consistent effects. The protective effect of lisinopril is detectable only in small (< 40% of LV) MIs.
dc.languageeng
dc.publisherDr Dietrich Steinkopff Verlag
dc.relationBasic Research In Cardiology
dc.relation5.723
dc.relation2,468
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmyocardial infarction
dc.subjectventricular remodeling
dc.subjectangiotensin-converting enzyme inhibitor
dc.subjectlisinopril
dc.subjectrat
dc.titleEarly rather than delayed administration of lisinopril protects the heart after myocardial infarction in rats
dc.typeArtículos de revistas


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