In Vitro Ultrasound Influence on Cutaneous Permeation of Hyaluronidase

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniv Metodista Piracicaba
dc.date.accessioned2014-05-20T13:24:56Z
dc.date.available2014-05-20T13:24:56Z
dc.date.created2014-05-20T13:24:56Z
dc.date.issued2010-01-01
dc.identifierJournal of Dispersion Science and Technology. Philadelphia: Taylor & Francis Inc, v. 31, n. 6, p. 756-759, 2010.
dc.identifier0193-2691
dc.identifierhttp://hdl.handle.net/11449/7870
dc.identifier10.1080/01932690903333051
dc.identifierWOS:000277725200009
dc.description.abstractIn vitro skin permeation of hyaluronidase enzyme and the ultrasound (US) effects on cutaneous permeation of this enzyme were investigated. Diffusion cell technique, porcine skins, buffer solution, and a hydrophilic gel+hyaluronidase (100 TUR/g), were used for study. The experimental groups were: gel+enzyme and gel+enzyme+US. The activity of permeated hyaluronidase was determined by turbydimetric method in spectrophotometer at 400nm. Gel+enzyme group permitted a diffusion of 26.89 +/- 3.82 TUR of hyaluronidase in the total time of 240 minutes. However, the other group did not produce significant differences (p0.05) in the same period (13.68 +/- 5.35 TUR). Hyaluronidase permeation through the skin was verified; however US did not cause increase of this enzyme permeation.
dc.languageeng
dc.publisherTaylor & Francis Inc
dc.relationJournal of Dispersion Science and Technology
dc.relation1.454
dc.relation0,375
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHyaluronidase
dc.subjectin vitro cutaneous permeation
dc.subjectultrasound
dc.titleIn Vitro Ultrasound Influence on Cutaneous Permeation of Hyaluronidase
dc.typeArtículos de revistas


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