| dc.contributor | Universidade Estadual Paulista (Unesp) | |
| dc.date.accessioned | 2014-05-20T13:24:54Z | |
| dc.date.available | 2014-05-20T13:24:54Z | |
| dc.date.created | 2014-05-20T13:24:54Z | |
| dc.date.issued | 2009-06-01 | |
| dc.identifier | Chromatographia. Wiesbaden: Vieweg, v. 69, p. 207-211, 2009. | |
| dc.identifier | 0009-5893 | |
| dc.identifier | http://hdl.handle.net/11449/7849 | |
| dc.identifier | 10.1365/s10337-009-1015-1 | |
| dc.identifier | WOS:000267330400016 | |
| dc.identifier | 9129780536724256 | |
| dc.description.abstract | A reversed phase LC method was developed and validated to analyze the in vitro release of AZT from microemulsions. A mobile phase of acetonitrile:water (15:85) was used. The method validation showed good selectivity and linearity (r = 0.9993) for sample concentrations ranging from 0.6 to 100.0 mu g mL(-1). The RSD values (0.7-4.3%) and percentage recovery (88.1-109.8%) were within acceptable limits. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.012 and 0.041 mu g mL(-1). Quantitative analysis of the values obtained in the drug release assay indicates that the microemulsions used promote sustained release of AZT, which follows a Fickian diffusion mechanism. | |
| dc.language | eng | |
| dc.publisher | Vieweg | |
| dc.relation | Chromatographia | |
| dc.relation | 1.401 | |
| dc.relation | 0,514 | |
| dc.rights | Acesso restrito | |
| dc.source | Web of Science | |
| dc.subject | Column liquid chromatography | |
| dc.subject | In vitro drug release | |
| dc.subject | Drug delivery system | |
| dc.subject | Zidovudine | |
| dc.title | LC Evaluation of In Vitro Release of AZT from Microemulsions | |
| dc.type | Artículos de revistas | |
