Synthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorInstituto Adolfo Lutz (IAL)
dc.date.accessioned2014-05-20T13:24:31Z
dc.date.available2014-05-20T13:24:31Z
dc.date.created2014-05-20T13:24:31Z
dc.date.issued2007-10-01
dc.identifierArchiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 340, n. 10, p. 538-542, 2007.
dc.identifier0365-6233
dc.identifierhttp://hdl.handle.net/11449/7633
dc.identifier10.1002/ardp.200700040
dc.identifierWOS:000250488600005
dc.description.abstractThe present work describes the synthesis and antimycobacterial activity of three Ag(I)-complexes with the sweeteners aspartame, saccharin, and cyclamate as ligands, with the aim of finding new candidate substances for fighting tuberculosis and other mycobacterial infections. The minimal inhibitory concentration of these three complexes was investigated in order to determine their in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium malmoense, and Mycobacterium kansasii. The MIC values were determined using the Microplate Alamar Blue Assay. The best MIC values found for the complexes were 9.75 mu M for Ag(l)-aspartame against M. kansasii and 15.7 mu M for Ag(I)-cyclamate against M. tuberculosis.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationArchiv Der Pharmazie
dc.relation2.288
dc.relation0,413
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectantimycobacterial activity
dc.subjectMABA
dc.subjectsilver-aspartame
dc.subjectsilver-cyclamate
dc.subjectsilver-saccharin
dc.titleSynthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes
dc.typeArtículos de revistas


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