Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.contributorInstituto Adolfo Lutz (IAL)
dc.date.accessioned2014-05-20T13:24:28Z
dc.date.available2014-05-20T13:24:28Z
dc.date.created2014-05-20T13:24:28Z
dc.date.issued2006-06-01
dc.identifierArchiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 339, n. 6, p. 283-290, 2006.
dc.identifier0365-6233
dc.identifierhttp://hdl.handle.net/11449/7598
dc.identifier10.1002/ardp.200500039
dc.identifierWOS:000238395100001
dc.description.abstractPyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and micelle diameter. The CMC was found by observing the solubility of Sudan III in Poly(ethylene glycol)-poly(pyrazinamidomethyl aspartate) copolymer (PEG-PASP-PZA) solutions. The mean diameter of PEG-PASP-PZA micelles, obtained by analyzing the dynamic light-scattering data, was 78.2 nm. The PEG-PASP-PZA derivative, when assayed for anti-Mycobacterium activity, exhibited stronger activity than the simple drug.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationArchiv Der Pharmazie
dc.relation2.288
dc.relation0,413
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpyrazinamide
dc.subjectmicelle-forming polymer
dc.subjecttuberculostatic prodrug
dc.titlePotential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
dc.typeArtículos de revistas


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